Azithromycin and Digoxin Interaction
Drug interaction information between Azithromycin and Digoxin.
Azithromycin and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Azithromycin and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
It is not yet fully known how these drugs interact, but azithromycin might change how your body handles digoxin.
FDA Label Information
7.3 Potential Drug-Drug Interaction with Macrolides Interactions with digoxin, colchicine or phenytoin have not been reported in clinical trials with azithromycin. Until further data are developed regarding drug interactions when digoxin, colchicine or phenytoin are used with azithromycin careful monitoring of patients is advised.
Azithromycin Also Interacts With
- Theophylline major
- Warfarin minor
- Colchicine minor
- Phenytoin minor
- Desloratadine minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Azithromycin + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Azithromycin's 9. In the minor band specifically: Azithromycin has 8 (also Warfarin, Colchicine, Phenytoin, Desloratadine); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Azithromycin and Digoxin?
It is not yet fully known how these drugs interact, but azithromycin might change how your body handles digoxin.
Digoxin carries more major-labeled pairs than Azithromycin
SPL source-record counts only. This page's band is minor · classes on file: Azithromycin (Macrolide Antibiotic); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Azithromycin's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Azithromycin
- Warfarin
- Colchicine
- Phenytoin
- Desloratadine
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.