Desloratadine and Fluoxetine Interaction
Drug interaction information between Desloratadine and Fluoxetine.
Desloratadine and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desloratadine and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine slows down how your body breaks down desloratadine, which leads to higher levels of the allergy medicine in your blood. However, these higher levels are not known to cause any extra safety problems.
FDA Label Information
[ See Clinical Pharmacology (12.3) .] 7.2 Fluoxetine In controlled clinical studies co-administration of desloratadine with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), resulted in increased plasma concentrations of desloratadine and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of desloratadine.
Desloratadine Also Interacts With
- Azithromycin minor
- Ketoconazole minor
- Erythromycin minor
- Cimetidine minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Desloratadine + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Desloratadine's 5. In the minor band specifically: Desloratadine has 5 (also Azithromycin, Ketoconazole, Erythromycin, Cimetidine); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Desloratadine and Fluoxetine?
Fluoxetine slows down how your body breaks down desloratadine, which leads to higher levels of the allergy medicine in your blood. However, these higher levels are not known to cause any extra safety problems.
Fluoxetine carries more major-labeled pairs than Desloratadine
SPL source-record counts only. This page's band is minor · classes on file: Desloratadine (Second-Generation Antihistamine); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Desloratadine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Desloratadine
- Azithromycin
- Ketoconazole
- Erythromycin
- Cimetidine
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.