What the FDA labels say about taking them together
Desloratadine and fluoxetine
Desloratadine's FDA label of May 17, 2025 names fluoxetine in its drug interactions section; the fluoxetine label PlainMeds reads does not name desloratadine. The desloratadine label: “In controlled clinical studies co-administration of desloratadine with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), resulted in increased plasma concentrations of desloratadine and 3 …”
Check it at the source: the desloratadine FDA label on DailyMed (effective May 17, 2025, Organon LLC); the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company).
What does the desloratadine label say about fluoxetine?
Desloratadine label, drug interactionsIn controlled clinical studies co-administration of desloratadine with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), resulted in increased plasma concentrations of desloratadine and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of desloratadine. [See Clinical Pharmacology (12.3) .]
Source: FDA drug label (Clarinex), Organon LLC, effective May 17, 2025 (SPL set c671342e-69a2-4ca5-abc2-8166ed4240d4), via openFDA; the full label on DailyMed
What does the fluoxetine label say about desloratadine?
Fluoxetine's label (effective January 8, 2026) does not name desloratadine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Desloratadine | Fluoxetine | |
|---|---|---|
| Labeled for | Allergies | Depression, Anxiety, Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.258 per tablet 5 mg tablet | $0.0519 per capsule 40 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once