dapagliflozin vs valsartan
Side-by-side comparison of dapagliflozin and valsartan. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓22%, ↑11%] ↓22% [↓27%, ↓17%] Nonsteroidal Anti-inflammatory Agent Mefenamic Acid (loading dose of...
Recommendation: Your doctor does not need to adjust your dosage for this combination.
Farxiga
Diovan
Dapagliflozin (Farxiga) helps lower blood sugar in adults with type 2 diabetes. It also helps adults with heart failure or chronic kidney disease.
Entresto is a medicine that combines two drugs to help adults and children with heart failure. It can lower the risk of death and hospitalization.
This medicine can help adults with chronic kidney disease by reducing the risk of kidney problems, heart problems, and needing to go to the hospital for heart failure. It can also help adults with heart failure by reducing the risk of heart problems and needing urgent care for heart failure. For adults with type 2 diabetes, it can help lower the risk of needing to go to the hospital for heart failure.
Entresto is used to treat heart failure in adults and children aged one year and older. It helps people whose hearts don't pump blood well enough. It can reduce hospital visits and the risk of death from heart problems.
Dapagliflozin is a type of medicine called an SGLT2 inhibitor. It works in the kidneys to remove extra sugar from your body through your urine. This helps to lower your blood sugar levels.
Entresto works by blocking two substances in your body that can worsen heart failure. One substance is neprilysin, and the other is angiotensin II. By blocking these, Entresto helps your heart pump blood more easily and reduces strain.
- • Yeast infections of the vagina
- • Common cold
- • Urinary tract infections
- • Low blood pressure
- • High potassium levels in your blood
- • Cough
- • Dizziness
- • Kidney problems
- Death 7,017
- Tiredness 2,250
- Feeling sick to your stomach 2,218
- Feeling lightheaded 2,096
- Loose stools 2,074
- Feeling tired 5,476
- Feeling lightheaded 5,251
- Difficulty breathing 5,251
- Feeling sick to your stomach 5,164
- Loose stools 4,581
Dapagliflozin can cause a serious condition called diabetic ketoacidosis (DKA), especially if you have type 1 diabetes. Symptoms include nausea, vomiting, stomach pain, and trouble breathing. If you have these symptoms, stop taking this medicine and get medical help right away. This medicine can also cause serious infections in the area between your genitals and anus. Get medical help right away if you have pain, tenderness, redness, or swelling in this area, along with a fever or feeling unwell.
Entresto can harm your unborn baby, even causing death. If you are pregnant or become pregnant, stop taking Entresto right away and tell your doctor.
This medicine may harm your unborn baby, especially during the second and third trimesters. It is not recommended while breastfeeding.
Entresto can cause serious harm or death to an unborn baby. Do not take this medicine if you are pregnant. Breastfeeding is not recommended while taking Entresto.
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How to Read This dapagliflozin vs valsartan Comparison
dapagliflozin is classified in the SGLT2 Inhibitor drug class, while valsartan sits within the Angiotensin II Receptor Blocker (ARB) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dapagliflozin has 15,655 submissions while valsartan has 25,723. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to there is a slight change in drug levels, but it is not large enough to affect how the medicine works.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between dapagliflozin and valsartan - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.