Butorphanol and Hydromorphone Interaction
Drug interaction information between Butorphanol and Hydromorphone.
Butorphanol and Hydromorphone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Butorphanol and Hydromorphone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Butorphanol can interfere with hydromorphone by blocking the same receptors that help relieve pain. This can make your pain medicine work less effectively or cause withdrawal symptoms.
FDA Label Information
Examples: Butorphanol, nalbuphine, pentazocine, and buprenorphine.
Butorphanol Also Interacts With
- Oxycodone moderate
- Acetaminophen/Oxycodone minor
- Buprenorphine (Pain) minor
- Codeine minor
- Fentanyl minor
Hydromorphone Also Interacts With
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Linezolid minor
Frequently Asked Questions
What SPL severity band is on file for Butorphanol + Hydromorphone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydromorphone has 13 labeled pairs on file vs Butorphanol's 11. In the minor band specifically: Butorphanol has 10 (also Acetaminophen/Oxycodone, Buprenorphine, Codeine, Fentanyl); Hydromorphone has 13 (also Trazodone, Tramadol, Cyclobenzaprine, Mirtazapine).
What mechanism field is on file for Butorphanol and Hydromorphone?
Butorphanol can interfere with hydromorphone by blocking the same receptors that help relieve pain. This can make your pain medicine work less effectively or cause withdrawal symptoms.
Hydromorphone's labeled portfolio outnumbers Butorphanol
SPL source-record counts only. This page's band is minor · classes on file: Butorphanol (Opioid Agonist-Antagonist); Hydromorphone (Opioid Analgesic).
0 major · 1 moderate · 10 minor · 11 total
- Other minor peers for Butorphanol
- Acetaminophen/Oxycodone
- Buprenorphine
- Codeine
- Fentanyl
0 major · 0 moderate · 13 minor · 13 total
- Other minor peers for Hydromorphone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Mirtazapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.