Butorphanol and Acetaminophen/Oxycodone Interaction
Drug interaction information between Butorphanol and Acetaminophen/Oxycodone.
Butorphanol and Acetaminophen/Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Butorphanol and Acetaminophen/Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Butorphanol can block the pain-relieving effects of oxycodone and may cause sudden withdrawal symptoms. This happens because the two drugs compete for the same spots in your body's nervous system.
FDA Label Information
Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics The concomitant use of opioids with other opioid analgesics, such as butorphanol, nalbuphine, pentazocine, may reduce the analgesic effect of PERCOCET and/or precipitate withdrawal symptoms.
Butorphanol Also Interacts With
- Oxycodone moderate
- Buprenorphine (Pain) minor
- Codeine minor
- Fentanyl minor
- Hydromorphone minor
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Frequently Asked Questions
What SPL severity band is on file for Butorphanol + Acetaminophen/Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Acetaminophen/Oxycodone has 23 labeled pairs on file vs Butorphanol's 11. In the minor band specifically: Butorphanol has 10 (also Buprenorphine, Codeine, Fentanyl, Hydromorphone); Acetaminophen/Oxycodone has 21 (also Trazodone, Tramadol, Cyclobenzaprine, Oxycodone).
What mechanism field is on file for Butorphanol and Acetaminophen/Oxycodone?
Butorphanol can block the pain-relieving effects of oxycodone and may cause sudden withdrawal symptoms. This happens because the two drugs compete for the same spots in your body's nervous system.
Acetaminophen/Oxycodone's labeled portfolio outnumbers Butorphanol
SPL source-record counts only. This page's band is minor · classes on file: Butorphanol (Opioid Agonist-Antagonist); Acetaminophen/Oxycodone (Opioid Analgesic Combination).
0 major · 1 moderate · 10 minor · 11 total
- Other minor peers for Butorphanol
- Buprenorphine
- Codeine
- Fentanyl
- Hydromorphone
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen/Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.