Butorphanol and Codeine Interaction
Drug interaction information between Butorphanol and Codeine.
Butorphanol and Codeine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Butorphanol and Codeine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Butorphanol can block the pain-relieving effects of codeine and may cause sudden, uncomfortable withdrawal symptoms.
FDA Label Information
Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics The concomitant use of opioids with other opioid analgesics, such as butorphanol, nalbuphine, pentazocine, may reduce the analgesic effect of acetaminophen and codeine phosphate tablets and/or precipitate withdrawal symptoms.
Butorphanol Also Interacts With
- Oxycodone moderate
- Acetaminophen/Oxycodone minor
- Buprenorphine (Pain) minor
- Fentanyl minor
- Hydromorphone minor
Codeine Also Interacts With
- Bupropion minor
- Fluoxetine minor
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Frequently Asked Questions
What SPL severity band is on file for Butorphanol + Codeine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Codeine has 27 labeled pairs on file vs Butorphanol's 11. In the minor band specifically: Butorphanol has 10 (also Acetaminophen/Oxycodone, Buprenorphine, Fentanyl, Hydromorphone); Codeine has 27 (also Bupropion, Fluoxetine, Trazodone, Tramadol).
What mechanism field is on file for Butorphanol and Codeine?
Butorphanol can block the pain-relieving effects of codeine and may cause sudden, uncomfortable withdrawal symptoms.
Codeine's labeled portfolio outnumbers Butorphanol
SPL source-record counts only. This page's band is minor · classes on file: Butorphanol (Opioid Agonist-Antagonist); Codeine (Opioid Analgesic).
0 major · 1 moderate · 10 minor · 11 total
- Other minor peers for Butorphanol
- Acetaminophen/Oxycodone
- Buprenorphine
- Fentanyl
- Hydromorphone
0 major · 0 moderate · 27 minor · 27 total
- Other minor peers for Codeine
- Bupropion
- Fluoxetine
- Trazodone
- Tramadol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.