Butorphanol and Buprenorphine Interaction
Drug interaction information between Butorphanol and Buprenorphine.
Butorphanol and Buprenorphine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Butorphanol and Buprenorphine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines can work together to slow your breathing and make your muscles very weak. This increases the risk of serious breathing problems.
FDA Label Information
Examples: butorphanol, nalbuphine, pentazocine Muscle Relaxants Clinical Impact: Buprenorphine may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression.
Butorphanol Also Interacts With
- Oxycodone moderate
- Acetaminophen/Oxycodone minor
- Codeine minor
- Fentanyl minor
- Hydromorphone minor
Buprenorphine Also Interacts With
- Gabapentin minor
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Pregabalin minor
Frequently Asked Questions
What SPL severity band is on file for Butorphanol + Buprenorphine (Pain)?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Buprenorphine has 19 labeled pairs on file vs Butorphanol's 11. In the minor band specifically: Butorphanol has 10 (also Acetaminophen/Oxycodone, Codeine, Fentanyl, Hydromorphone); Buprenorphine has 19 (also Gabapentin, Trazodone, Tramadol, Cyclobenzaprine).
What mechanism field is on file for Butorphanol and Buprenorphine (Pain)?
These medicines can work together to slow your breathing and make your muscles very weak. This increases the risk of serious breathing problems.
Buprenorphine's labeled portfolio outnumbers Butorphanol
SPL source-record counts only. This page's band is minor · classes on file: Butorphanol (Opioid Agonist-Antagonist); Buprenorphine (Partial Opioid Agonist).
0 major · 1 moderate · 10 minor · 11 total
- Other minor peers for Butorphanol
- Acetaminophen/Oxycodone
- Codeine
- Fentanyl
- Hydromorphone
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Buprenorphine
- Gabapentin
- Trazodone
- Tramadol
- Cyclobenzaprine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.