Brimonidine/Timolol and Clonidine Interaction
Drug interaction information between Brimonidine/Timolol and Clonidine.
Brimonidine/Timolol and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Brimonidine/Timolol and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs work in a similar way to lower blood pressure. Taking them together can cause an additive effect, which might make your blood pressure drop too low.
FDA Label Information
( 7.7 ) Tricyclic antidepressants may potentially blunt the hypotensive effect of systemic clonidine. 7.8 Tricyclic Antidepressants Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Brimonidine/Timolol + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Brimonidine/Timolol's 2. In the minor band specifically: Brimonidine/Timolol has 2 (also Timolol); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Brimonidine/Timolol and Clonidine?
Both drugs work in a similar way to lower blood pressure. Taking them together can cause an additive effect, which might make your blood pressure drop too low.
Clonidine's labeled portfolio outnumbers Brimonidine/Timolol
SPL source-record counts only. This page's band is minor · classes on file: Brimonidine/Timolol (Alpha-2 Agonist / Beta-Blocker Combination); Clonidine (Central Alpha-2 Agonist).
0 major · 0 moderate · 2 minor · 2 total
- Other minor peers for Brimonidine/Timolol
- Timolol
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.