Bempedoic Acid/Ezetimibe and Cholestyramine Interaction
Drug interaction information between Bempedoic Acid/Ezetimibe and Cholestyramine.
Bempedoic Acid/Ezetimibe and Cholestyramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bempedoic Acid/Ezetimibe and Cholestyramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cholestyramine can bind to the other medicine, which prevents your body from absorbing it correctly.
FDA Label Information
Cholestyramine Clinical Impact: Concomitant use of NEXLIZET and cholestyramine decreases ezetimibe concentration. Intervention: Administer NEXLIZET either at least 2 hours before or at least 4 hours after bile acid sequestrants [see Dosage and Administration (2.2) ] .
Bempedoic Acid/Ezetimibe Also Interacts With
- Simvastatin moderate
- Pravastatin moderate
- Fenofibrate moderate
- Bempedoic Acid moderate
- Ezetimibe minor
Cholestyramine Also Interacts With
- Naproxen moderate
- Olmesartan moderate
- Raloxifene moderate
- Propranolol minor
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Bempedoic Acid/Ezetimibe + Cholestyramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cholestyramine has 34 labeled pairs on file vs Bempedoic Acid/Ezetimibe's 7. In the minor band specifically: Bempedoic Acid/Ezetimibe has 3 (also Ezetimibe, Cyclosporine); Cholestyramine has 31 (also Propranolol, Warfarin, Tetracycline, Phenobarbital).
What mechanism field is on file for Bempedoic Acid/Ezetimibe and Cholestyramine?
Cholestyramine can bind to the other medicine, which prevents your body from absorbing it correctly.
Cholestyramine's labeled portfolio outnumbers Bempedoic Acid/Ezetimibe
SPL source-record counts only. This page's band is minor · classes on file: Bempedoic Acid/Ezetimibe (ACL Inhibitor / Cholesterol Absorption Inhibitor); Cholestyramine (Bile Acid Sequestrant).
0 major · 4 moderate · 3 minor · 7 total
- Other minor peers for Bempedoic Acid/Ezetimibe
- Ezetimibe
- Cyclosporine
0 major · 3 moderate · 31 minor · 34 total
- Other minor peers for Cholestyramine
- Propranolol
- Warfarin
- Tetracycline
- Phenobarbital
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.