What the FDA labels say about taking them together
Alendronate and levothyroxine
Alendronate's FDA label (Binosto) of February 6, 2026 names levothyroxine in its drug interactions section; the levothyroxine labels PlainMeds reads (4) do not name alendronate. The alendronate label: “The bioavailability of alendronate was slightly decreased when BINOSTO and levothyroxine were co-administered to healthy subjects.”
Check it at the source: the alendronate FDA label on DailyMed (effective March 12, 2026, Organon LLC); the levothyroxine FDA label on DailyMed (effective February 20, 2024, AbbVie Inc.).
What does the alendronate label say about levothyroxine?
Binosto label (Radius Health, Inc., February 6, 2026), drug interactionsThe bioavailability of alendronate was slightly decreased when BINOSTO and levothyroxine were co-administered to healthy subjects [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Binosto, NDA202344), Radius Health, Inc., effective February 6, 2026 (SPL set 09765234-01bc-40f7-b9bb-c167056f3909), via openFDA
Source: FDA drug label (FOSAMAX), Organon LLC, effective March 12, 2026 (SPL set 14e931fd-2c5f-4d90-b7db-5980706f4a56), via openFDA; the full label on DailyMed
What does the levothyroxine label say about alendronate?
Levothyroxine's label (effective February 20, 2024) and its 3 other brand-application labels do not name alendronate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Synthroid), AbbVie Inc., effective February 20, 2024 (SPL set 1e11ad30-1041-4520-10b0-8f9d30d30fcc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alendronate | Levothyroxine | |
|---|---|---|
| Labeled for | Osteoporosis | Hypothyroidism |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.256 per tablet 70 mg tablet | $0.0588 per tablet 112 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once