Alendronate and Levothyroxine Interaction
Drug interaction information between Alendronate and Levothyroxine.
Alendronate and Levothyroxine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alendronate and Levothyroxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs at the same time can prevent the body from absorbing enough alendronate into the system.
FDA Label Information
7.4 Levothyroxine The bioavailability of alendronate was slightly decreased when BINOSTO and levothyroxine were co-administered to healthy subjects [see Clinical Pharmacology (12.3) ] .
Levothyroxine Also Interacts With
- Sertraline minor
- Furosemide minor
- Propranolol minor
- Ferrous Sulfate minor
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Alendronate + Levothyroxine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Levothyroxine has 22 labeled pairs on file vs Alendronate's 2. In the minor band specifically: Alendronate has 1; Levothyroxine has 22 (also Sertraline, Furosemide, Propranolol, Ferrous Sulfate).
What mechanism field is on file for Alendronate and Levothyroxine?
Taking these two drugs at the same time can prevent the body from absorbing enough alendronate into the system.
Levothyroxine's labeled portfolio outnumbers Alendronate
SPL source-record counts only. This page's band is minor · classes on file: Alendronate (Bisphosphonate); Levothyroxine (Thyroid Hormone).
0 major · 1 moderate · 1 minor · 2 total
Alendronate has no other minor-band peer in this dataset besides Levothyroxine.
0 major · 0 moderate · 22 minor · 22 total
- Other minor peers for Levothyroxine
- Sertraline
- Furosemide
- Propranolol
- Ferrous Sulfate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.