Ganciclovir and Trimethoprim Interaction
Drug interaction information between Ganciclovir and Trimethoprim.
Ganciclovir and Trimethoprim have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ganciclovir and Trimethoprim. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both medications can be hard on the kidneys and may lower your blood cell counts. Using them at the same time increases the chance of these serious side effects.
FDA Label Information
Other drugs associated with myelosuppression or nephrotoxicity (e.g., dapsone, doxorubicin, flucytosine, hydroxyurea, pentamidine, tacrolimus, trimethoprim/ sulfamethoxazole, vinblastine, vincristine and zidovudine) Unknown Because of potential for higher toxicity, coadministration with Ganciclovir Injection should be considered only if the potential benefits are judged to outweigh the risks.
Ganciclovir Also Interacts With
- Cyclosporine moderate
- Amphotericin B moderate
- Probenecid minor
- Bictegravir/Emtricitabine/Tenofovir minor
- Emtricitabine/Tenofovir minor
Trimethoprim Also Interacts With
- Theophylline major
- Prenatal Multivitamin moderate
- Spironolactone moderate
- Spironolactone (Acne) moderate
- Metformin minor
Frequently Asked Questions
What SPL severity band is on file for Ganciclovir + Trimethoprim?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Trimethoprim has 22 labeled pairs on file vs Ganciclovir's 9. In the minor band specifically: Ganciclovir has 7 (also Probenecid, Bictegravir, Emtricitabine/Tenofovir, Imipenem/Cilastatin); Trimethoprim has 18 (also Metformin, Glipizide, Warfarin, Methotrexate).
What mechanism field is on file for Ganciclovir and Trimethoprim?
Both medications can be hard on the kidneys and may lower your blood cell counts. Using them at the same time increases the chance of these serious side effects.
Trimethoprim carries more major-labeled pairs than Ganciclovir
SPL source-record counts only. This page's band is minor · classes on file: Ganciclovir (Antiviral (Nucleoside Analog)); Trimethoprim (Dihydrofolate Reductase Inhibitor).
Trimethoprim has 1 major-labeled pair vs Ganciclovir's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 7 minor · 9 total
- Other minor peers for Ganciclovir
- Probenecid
- Bictegravir
- Emtricitabine/Tenofovir
- Imipenem/Cilastatin
1 major · 3 moderate · 18 minor · 22 total
- Other minor peers for Trimethoprim
- Metformin
- Glipizide
- Warfarin
- Methotrexate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.