Ganciclovir and Probenecid Interaction
Drug interaction information between Ganciclovir and Probenecid.
Ganciclovir and Probenecid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ganciclovir and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid makes it harder for your body to remove ganciclovir, causing the drug to stay in your system longer.
FDA Label Information
Probenecid ↑ Ganciclovir Ganciclovir Injection dose may need to be reduced. (7) Probenecid: May increase ganciclovir levels.
Ganciclovir Also Interacts With
- Cyclosporine moderate
- Amphotericin B moderate
- Trimethoprim minor
- Bictegravir/Emtricitabine/Tenofovir minor
- Emtricitabine/Tenofovir minor
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
What SPL severity band is on file for Ganciclovir + Probenecid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Ganciclovir's 9. In the minor band specifically: Ganciclovir has 7 (also Trimethoprim, Bictegravir, Emtricitabine/Tenofovir, Imipenem/Cilastatin); Probenecid has 23 (also Theophylline, Acetaminophen/Oxycodone, Ampicillin/Sulbactam, Carbidopa/Levodopa).
What mechanism field is on file for Ganciclovir and Probenecid?
Probenecid makes it harder for your body to remove ganciclovir, causing the drug to stay in your system longer.
Probenecid carries more major-labeled pairs than Ganciclovir
SPL source-record counts only. This page's band is minor · classes on file: Ganciclovir (Antiviral (Nucleoside Analog)); Probenecid (Uricosuric Agent).
Probenecid has 2 major-labeled pairs vs Ganciclovir's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 7 minor · 9 total
- Other minor peers for Ganciclovir
- Trimethoprim
- Bictegravir
- Emtricitabine/Tenofovir
- Imipenem/Cilastatin
2 major · 12 moderate · 23 minor · 37 total
- Other minor peers for Probenecid
- Theophylline
- Acetaminophen/Oxycodone
- Ampicillin/Sulbactam
- Carbidopa/Levodopa
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.