Ganciclovir and Probenecid Interaction
Drug interaction information between Ganciclovir and Probenecid.
Ganciclovir and Probenecid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ganciclovir and Probenecid. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Probenecid makes it harder for your body to remove ganciclovir, causing the drug to stay in your system longer.
What To Do
Your doctor may need to lower your dose of ganciclovir to prevent side effects.
FDA Label Information
Probenecid ↑ Ganciclovir Ganciclovir Injection dose may need to be reduced. (7) Probenecid: May increase ganciclovir levels.
Ganciclovir Also Interacts With
- Cyclosporine moderate
- Amphotericin B moderate
- Trimethoprim minor
- Bictegravir/Emtricitabine/Tenofovir minor
- Emtricitabine/Tenofovir minor
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
Can I take Ganciclovir and Probenecid together?
This is a minor interaction. Your doctor may need to lower your dose of ganciclovir to prevent side effects.
How serious is the interaction between Ganciclovir and Probenecid?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Ganciclovir and Probenecid interact?
Probenecid makes it harder for your body to remove ganciclovir, causing the drug to stay in your system longer.
Understanding the Ganciclovir and Probenecid Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Ganciclovir belongs to the Antiviral (Nucleoside Analog) class and Probenecid belongs to the Uricosuric Agent class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Probenecid makes it harder for your body to remove ganciclovir, causing the drug to stay in your system longer. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Ganciclovir has 9 total documented interactions on file in this dataset, and Probenecid has 37. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to lower your dose of ganciclovir to prevent side effects. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Ganciclovir or Probenecid based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.