Ganciclovir and Cyclosporine Interaction
Drug interaction information between Ganciclovir and Cyclosporine.
Ganciclovir and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ganciclovir and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together increases the risk of kidney damage. This can be seen through an increase in creatinine, a waste product that the kidneys usually filter out.
FDA Label Information
Cyclosporine or amphotericin B Unknown Monitor renal function when Ganciclovir Injection is coadministered with cyclosporine or amphotericin B because of potential increase in serum creatinine [see Warnings and Precautions (5.2)]. (7) Cyclosporine or amphotericin B: When coadministered with ganciclovir, the risk of nephrotoxicity may be increased.
Ganciclovir Also Interacts With
- Amphotericin B moderate
- Trimethoprim minor
- Probenecid minor
- Bictegravir/Emtricitabine/Tenofovir minor
- Emtricitabine/Tenofovir minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Ganciclovir + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Ganciclovir's 9. In the moderate band specifically: Ganciclovir has 2 (also Amphotericin B); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Ganciclovir and Cyclosporine?
Taking these two drugs together increases the risk of kidney damage. This can be seen through an increase in creatinine, a waste product that the kidneys usually filter out.
Cyclosporine carries more major-labeled pairs than Ganciclovir
SPL source-record counts only. This page's band is moderate · classes on file: Ganciclovir (Antiviral (Nucleoside Analog)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Ganciclovir's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 7 minor · 9 total
- Other moderate peers for Ganciclovir
- Amphotericin B
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.