Amoxicillin and Ethinyl Estradiol Interaction
Drug interaction information between Amoxicillin and Ethinyl Estradiol.
Amoxicillin and Ethinyl Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amoxicillin and Ethinyl Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amoxicillin does not change the levels of birth control hormones in your blood.
FDA Label Information
The serum concentrations of etonogestrel and ethinyl estradiol were not affected by concomitant administration of oral amoxicillin or doxycycline in standard dosages during 10 days of antibiotic treatment.
Amoxicillin Also Interacts With
- Lansoprazole major
- Rabeprazole major
- Theophylline major
- Allopurinol moderate
- Probenecid moderate
Ethinyl Estradiol Also Interacts With
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Estradiol minor
- Lamotrigine minor
- Topiramate minor
Frequently Asked Questions
What SPL severity band is on file for Amoxicillin + Ethinyl Estradiol/Etonogestrel?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ethinyl Estradiol has 28 labeled pairs on file vs Amoxicillin's 12. In the minor band specifically: Amoxicillin has 7 (also Estradiol, Progesterone, Amoxicillin/Clavulanate, Etonogestrel); Ethinyl Estradiol has 27 (also Atorvastatin, Estradiol, Lamotrigine, Topiramate).
What mechanism field is on file for Amoxicillin and Ethinyl Estradiol/Etonogestrel?
Amoxicillin does not change the levels of birth control hormones in your blood.
Amoxicillin carries more major-labeled pairs than Ethinyl Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Amoxicillin (Penicillin Antibiotic); Ethinyl Estradiol (Vaginal Contraceptive Ring).
Amoxicillin has 3 major-labeled pairs vs Ethinyl Estradiol's 0. This page itself is in the minor band, not the major band.
3 major · 2 moderate · 7 minor · 12 total
- Other minor peers for Amoxicillin
- Estradiol
- Progesterone
- Amoxicillin/Clavulanate
- Etonogestrel
0 major · 1 moderate · 27 minor · 28 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Estradiol
- Lamotrigine
- Topiramate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.