Ethinyl Estradiol and Topiramate Interaction
Drug interaction information between Ethinyl Estradiol and Topiramate.
Ethinyl Estradiol and Topiramate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethinyl Estradiol and Topiramate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine can lower the amount of birth control in your blood, making it less effective at preventing pregnancy.
FDA Label Information
Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include: phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St.
Ethinyl Estradiol Also Interacts With
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Amoxicillin minor
- Estradiol minor
- Lamotrigine minor
Topiramate Also Interacts With
- Zonisamide moderate
- Alogliptin moderate
- Ertugliflozin moderate
- Hydrochlorothiazide minor
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Ethinyl Estradiol/Etonogestrel + Topiramate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Topiramate has 30 labeled pairs on file vs Ethinyl Estradiol's 28. In the minor band specifically: Ethinyl Estradiol has 27 (also Atorvastatin, Amoxicillin, Estradiol, Lamotrigine); Topiramate has 27 (also Hydrochlorothiazide, Amitriptyline, Pioglitazone, Carbamazepine).
What mechanism field is on file for Ethinyl Estradiol/Etonogestrel and Topiramate?
This medicine can lower the amount of birth control in your blood, making it less effective at preventing pregnancy.
Topiramate's labeled portfolio outnumbers Ethinyl Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Ethinyl Estradiol (Vaginal Contraceptive Ring); Topiramate (Anticonvulsant).
0 major · 1 moderate · 27 minor · 28 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Amoxicillin
- Estradiol
- Lamotrigine
0 major · 3 moderate · 27 minor · 30 total
- Other minor peers for Topiramate
- Hydrochlorothiazide
- Amitriptyline
- Pioglitazone
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.