Amoxicillin and Progesterone Interaction
Drug interaction information between Amoxicillin and Progesterone.
Amoxicillin and Progesterone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amoxicillin and Progesterone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antibiotic changes the bacteria in your gut, which can prevent your body from absorbing birth control hormones properly.
FDA Label Information
7.4 Oral Contraceptives Amoxicillin and Clavulanate Potassium may affect intestinal flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
Amoxicillin Also Interacts With
- Lansoprazole major
- Rabeprazole major
- Theophylline major
- Allopurinol moderate
- Probenecid moderate
Progesterone Also Interacts With
- Isotretinoin major
- Theophylline major
- Amoxicillin/Clavulanate minor
- Medroxyprogesterone minor
- Phenobarbital minor
Frequently Asked Questions
What SPL severity band is on file for Amoxicillin + Progesterone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amoxicillin has 12 labeled pairs on file vs Progesterone's 7. In the minor band specifically: Amoxicillin has 7 (also Estradiol, Amoxicillin/Clavulanate, Ethinyl Estradiol, Etonogestrel); Progesterone has 5 (also Amoxicillin/Clavulanate, Medroxyprogesterone, Phenobarbital, Ziprasidone).
What mechanism field is on file for Amoxicillin and Progesterone?
This antibiotic changes the bacteria in your gut, which can prevent your body from absorbing birth control hormones properly.
Amoxicillin carries more major-labeled pairs than Progesterone
SPL source-record counts only. This page's band is minor · classes on file: Amoxicillin (Penicillin Antibiotic); Progesterone (Progestogen Hormone).
Amoxicillin has 3 major-labeled pairs vs Progesterone's 2. This page itself is in the minor band, not the major band.
3 major · 2 moderate · 7 minor · 12 total
- Other minor peers for Amoxicillin
- Estradiol
- Amoxicillin/Clavulanate
- Ethinyl Estradiol
- Etonogestrel
2 major · 0 moderate · 5 minor · 7 total
- Other minor peers for Progesterone
- Amoxicillin/Clavulanate
- Medroxyprogesterone
- Phenobarbital
- Ziprasidone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.