Amoxicillin and Estradiol Interaction
Drug interaction information between Amoxicillin and Estradiol.
Amoxicillin and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amoxicillin and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking this antibiotic can temporarily lower the amount of estrogen hormones circulating in your blood.
FDA Label Information
Following administration of amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.
Amoxicillin Also Interacts With
- Lansoprazole major
- Rabeprazole major
- Theophylline major
- Allopurinol moderate
- Probenecid moderate
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Amoxicillin + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Amoxicillin's 12. In the minor band specifically: Amoxicillin has 7 (also Progesterone, Amoxicillin/Clavulanate, Ethinyl Estradiol, Etonogestrel); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Amoxicillin and Estradiol?
Taking this antibiotic can temporarily lower the amount of estrogen hormones circulating in your blood.
Amoxicillin carries more major-labeled pairs than Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Amoxicillin (Penicillin Antibiotic); Estradiol (Estrogen Hormone).
Amoxicillin has 3 major-labeled pairs vs Estradiol's 1. This page itself is in the minor band, not the major band.
3 major · 2 moderate · 7 minor · 12 total
- Other minor peers for Amoxicillin
- Progesterone
- Amoxicillin/Clavulanate
- Ethinyl Estradiol
- Etonogestrel
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.