What the FDA labels say about taking them together
Amoxicillin and estradiol
Amoxicillin's FDA label of February 22, 2024 names estradiol in its drug interactions section; the estradiol labels PlainMeds reads (4) do not name amoxicillin. The amoxicillin label: “Following administration of ampicillin or amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.”
Check it at the source: the amoxicillin FDA label on DailyMed (effective February 22, 2024, Sandoz Inc); the estradiol FDA label on DailyMed (effective April 3, 2024, Amneal Pharmaceuticals LLC).
What does the amoxicillin label say about estradiol?
Amoxicillin label, drug interactionsFollowing administration of ampicillin or amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.
Source: FDA drug label (Amoxicillin), Sandoz Inc, effective February 22, 2024 (SPL set 13bd4214-9b7f-425b-af5f-fc1ddc678230), via openFDA; the full label on DailyMed
What does the estradiol label say about amoxicillin?
Estradiol's label (effective April 3, 2024) and its 3 other brand-application labels do not name amoxicillin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (YUVAFEM), Amneal Pharmaceuticals LLC, effective April 3, 2024 (SPL set 30c7f6ba-7a9e-4853-b3e4-e00a46560224), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Which combination products and biosimilars carry the same label text?
Their labels quote the same sentences for their ingredient; each has its own page with its own label dates.
Both medicines on the record
| Amoxicillin | Estradiol | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Menopause symptoms, Breast cancer, Osteoporosis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0788 per capsule 500 mg capsule | $0.0635 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once