What the FDA labels say about taking them together
Amoxicillin and probenecid
Amoxicillin's FDA label of February 22, 2024 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name amoxicillin. The amoxicillin label: “Probenecid decreases the renal tubular secretion of amoxicillin.”
Check it at the source: the amoxicillin FDA label on DailyMed (effective February 22, 2024, Sandoz Inc); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the amoxicillin label say about probenecid?
Amoxicillin label, drug interactionsProbenecid decreases the renal tubular secretion of amoxicillin.
Source: FDA drug label (Amoxicillin), Sandoz Inc, effective February 22, 2024 (SPL set 13bd4214-9b7f-425b-af5f-fc1ddc678230), via openFDA; the full label on DailyMed
What does the probenecid label say about amoxicillin?
Probenecid's label (effective January 5, 2021) does not name amoxicillin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amoxicillin | Probenecid | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0788 per capsule 500 mg capsule | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once