Amlodipine/Benazepril and Amiloride Interaction
Drug interaction information between Amlodipine/Benazepril and Amiloride.
Amlodipine/Benazepril and Amiloride have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amlodipine/Benazepril and Amiloride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can cause the body to keep too much potassium instead of passing it through urine. This can lead to a dangerous buildup of potassium in your blood.
FDA Label Information
Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) or potassium supplements can increase the risk of hyperkalemia. Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) or potassium supplements can increase the risk of hyperkalemia.
Amlodipine/Benazepril Also Interacts With
- Amlodipine major
- Simvastatin major
- Lithium major
- Aliskiren major
- Spironolactone moderate
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Benazepril moderate
- Perindopril moderate
Frequently Asked Questions
What SPL severity band is on file for Amlodipine/Benazepril + Amiloride?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Amlodipine/Benazepril's 7. In the moderate band specifically: Amlodipine/Benazepril has 2 (also Spironolactone); Amiloride has 7 (also Cyclosporine, Lithium, Benazepril, Perindopril).
What mechanism field is on file for Amlodipine/Benazepril and Amiloride?
Both of these medications can cause the body to keep too much potassium instead of passing it through urine. This can lead to a dangerous buildup of potassium in your blood.
Amlodipine/Benazepril carries more major-labeled pairs than Amiloride
SPL source-record counts only. This page's band is moderate · classes on file: Amlodipine/Benazepril (Calcium Channel Blocker / ACE Inhibitor Combination); Amiloride (Potassium-Sparing Diuretic).
Amlodipine/Benazepril has 4 major-labeled pairs vs Amiloride's 1. This page itself is in the moderate band, not the major band.
4 major · 2 moderate · 1 minor · 7 total
- Other moderate peers for Amlodipine/Benazepril
- Spironolactone
1 major · 7 moderate · 11 minor · 19 total
- Other moderate peers for Amiloride
- Cyclosporine
- Lithium
- Benazepril
- Perindopril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.