Aliskiren and Potassium Chloride Interaction
Drug interaction information between Aliskiren and Potassium Chloride.
Aliskiren and Potassium Chloride have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Aliskiren and Potassium Chloride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aliskiren blocks a hormone that helps the body get rid of potassium, which can cause potassium levels to build up when taken with a supplement.
FDA Label Information
7.2 Renin-angiotensin-aldosterone Inhibitors Drugs that inhibit the renin-angiotensin-aldosterone system (RAAS) including angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), spironolactone, eplerenone, or aliskiren produce potassium retention by inhibiting aldosterone production.
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Potassium Chloride Also Interacts With
- Amiloride major
- Spironolactone minor
- Eplerenone minor
- Glycopyrrolate minor
- Prenatal Multivitamin minor
Frequently Asked Questions
What SPL severity band is on file for Aliskiren + Potassium Chloride?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Potassium Chloride's 6. In the minor band specifically: Aliskiren has 3 (also Furosemide, Potassium Citrate); Potassium Chloride has 5 (also Spironolactone, Eplerenone, Glycopyrrolate, Prenatal Multivitamin).
What mechanism field is on file for Aliskiren and Potassium Chloride?
Aliskiren blocks a hormone that helps the body get rid of potassium, which can cause potassium levels to build up when taken with a supplement.
Aliskiren carries more major-labeled pairs than Potassium Chloride
SPL source-record counts only. This page's band is minor · classes on file: Aliskiren (Direct Renin Inhibitor); Potassium Chloride (Electrolyte Supplement).
Aliskiren has 22 major-labeled pairs vs Potassium Chloride's 1. This page itself is in the minor band, not the major band.
22 major · 3 moderate · 3 minor · 28 total
- Other minor peers for Aliskiren
- Furosemide
- Potassium Citrate
1 major · 0 moderate · 5 minor · 6 total
- Other minor peers for Potassium Chloride
- Spironolactone
- Eplerenone
- Glycopyrrolate
- Prenatal Multivitamin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.