Potassium Chloride and Eplerenone Interaction
Drug interaction information between Potassium Chloride and Eplerenone.
Potassium Chloride and Eplerenone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Potassium Chloride and Eplerenone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications prevent your body from getting rid of potassium. Taking them together increases the risk of having too much potassium in your blood.
FDA Label Information
7.2 Renin-angiotensin-aldosterone Inhibitors Drugs that inhibit the renin-angiotensin-aldosterone system (RAAS) including angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), spironolactone, eplerenone, or aliskiren produce potassium retention by inhibiting aldosterone production.
Potassium Chloride Also Interacts With
- Amiloride major
- Spironolactone minor
- Aliskiren minor
- Glycopyrrolate minor
- Prenatal Multivitamin minor
Eplerenone Also Interacts With
- Fluconazole major
- Verapamil major
- Erythromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
Frequently Asked Questions
What SPL severity band is on file for Potassium Chloride + Eplerenone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Eplerenone has 12 labeled pairs on file vs Potassium Chloride's 6. In the minor band specifically: Potassium Chloride has 5 (also Spironolactone, Aliskiren, Glycopyrrolate, Prenatal Multivitamin); Eplerenone has 7 (also Lithium, Hydrochlorothiazide, Hydrochlorothiazide, Hydrochlorothiazide).
What mechanism field is on file for Potassium Chloride and Eplerenone?
Both of these medications prevent your body from getting rid of potassium. Taking them together increases the risk of having too much potassium in your blood.
Eplerenone carries more major-labeled pairs than Potassium Chloride
SPL source-record counts only. This page's band is minor · classes on file: Potassium Chloride (Electrolyte Supplement); Eplerenone (Aldosterone Antagonist).
Eplerenone has 5 major-labeled pairs vs Potassium Chloride's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 5 minor · 6 total
- Other minor peers for Potassium Chloride
- Spironolactone
- Aliskiren
- Glycopyrrolate
- Prenatal Multivitamin
5 major · 0 moderate · 7 minor · 12 total
- Other minor peers for Eplerenone
- Lithium
- Hydrochlorothiazide
- Hydrochlorothiazide
- Hydrochlorothiazide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.