What the FDA labels say about taking them together
Eplerenone and potassium chloride
Potassium chloride's FDA label of July 14, 2025 names eplerenone in its warnings section; eplerenone's label does not name potassium chloride itself but warns about its class (potassium salts).
Check it at the source: the eplerenone FDA label on DailyMed (effective June 23, 2025, Viatris Specialty LLC); the potassium chloride FDA label on DailyMed (effective July 14, 2025, Upsher-Smith Laboratories, LLC).
What does the eplerenone label say about potassium chloride?
Eplerenone's label does not name potassium chloride itself; it warns about its class (potassium salts):
Eplerenone label, contraindicationsconcomitant administration of potassium supplements or potassium-sparing diuretics (e.g., amiloride, spironolactone, or triamterene) [see Warnings and Precautions (5.1), Adverse Reactions (6.2), Drug Interactions (7), and Clinical Pharmacology (12.3) ].
Source: FDA drug label (Inspra), NDA021437 (Upjohn), as published by Viatris Specialty LLC, effective June 23, 2025 (SPL set 1a52bedc-8e2c-4116-a296-a87770676b4a), via openFDA; the full label on DailyMed
What does the potassium chloride label say about eplerenone?
Potassium chloride label, warningsInteraction with Renin-Angiotensin-Aldosterone System Inhibitors Drugs that inhibit the renin-angiotensin-aldosterone system (RAAS) including angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), spironolactone, eplerenone, or aliskiren produce potassium retention by inhibiting aldosterone production.
Source: FDA drug label (Klor-Con, NDA019123), Upsher-Smith Laboratories, LLC, effective July 14, 2025 (SPL set 1ff53330-065c-4213-9c0c-ac498621d09d), via openFDA
Source: FDA drug label (KLOR-CON M), Upsher-Smith Laboratories, LLC, effective July 14, 2025 (SPL set b89910f6-4ff5-4a62-8269-696f7c10e4f6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eplerenone | Potassium chloride | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.308 per tablet 25 mg tablet | $0.0828 per tablet 10 mEq tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once