Potassium Chloride and Amiloride Interaction
Drug interaction information between Potassium Chloride and Amiloride.
Potassium Chloride and Amiloride have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Potassium Chloride and Amiloride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines increase the amount of potassium in your blood, and taking them together can cause potassium levels to become dangerously high.
FDA Label Information
7 DRUG INTERACTIONS Triamterene and amiloride: Concomitant use is contraindicated (7.1) Renin-angiotensin-aldosterone inhibitors: Monitor for hyperkalemia (7.2) Nonsteroidal anti-inflammatory drugs: Monitor for hyperkalemia (7.3) 7.1 Triamterene or amiloride Use with triamterene or amiloride can produce severe hyperkalemia.
Potassium Chloride Also Interacts With
- Spironolactone minor
- Eplerenone minor
- Aliskiren minor
- Glycopyrrolate minor
- Prenatal Multivitamin minor
Amiloride Also Interacts With
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
- Perindopril moderate
Frequently Asked Questions
What SPL severity band is on file for Potassium Chloride + Amiloride?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Potassium Chloride's 6. In the major band specifically: Potassium Chloride has 1; Amiloride has 1.
What mechanism field is on file for Potassium Chloride and Amiloride?
Both of these medicines increase the amount of potassium in your blood, and taking them together can cause potassium levels to become dangerously high.
Amiloride's labeled portfolio outnumbers Potassium Chloride
SPL source-record counts only. This page's band is major · classes on file: Potassium Chloride (Electrolyte Supplement); Amiloride (Potassium-Sparing Diuretic).
1 major · 0 moderate · 5 minor · 6 total
Potassium Chloride has no other major-band peer in this dataset besides Amiloride.
1 major · 7 moderate · 11 minor · 19 total
Amiloride has no other major-band peer in this dataset besides Potassium Chloride.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.