What the FDA labels say about taking them together
Amiloride and potassium chloride
Potassium chloride's FDA label of July 14, 2025 names amiloride in its contraindications section; amiloride's label does not name potassium chloride itself but warns about its class (potassium salts). The potassium chloride label: “DRUG INTERACTIONS Triamterene and amiloride: Concomitant use is contraindicated Renin-angiotensin-aldosterone inhibitors:”
Check it at the source: the amiloride FDA label on DailyMed (effective May 5, 2023, Padagis US LLC); the potassium chloride FDA label on DailyMed (effective July 14, 2025, Upsher-Smith Laboratories, LLC).
What does the amiloride label say about potassium chloride?
Amiloride's label does not name potassium chloride itself; it warns about its class (potassium salts):
Amiloride label, contraindicationsPotassium supplementation in the form of medication, potassium-containing salt substitutes or a potassium-rich diet should not be used with amiloride HCl except in severe and/or refractory cases of hypokalemia.
Source: FDA drug label (amiloride hydrochloride), Padagis US LLC, effective May 5, 2023 (SPL set 2b70cf0c-45be-428f-b396-5001ed4e30fc), via openFDA; the full label on DailyMed
What does the potassium chloride label say about amiloride?
Potassium chloride label, contraindicationsHyperkalemia may complicate any of the following conditions: chronic renal failure, systemic acidosis, such as diabetic acidosis, acute dehydration, extensive tissue breakdown as in severe burns, adrenal insufficiency, or the administration of a potassium-sparing diuretic (e.g., spironolactone, triamterene, or amiloride) [see OVERDOSAGE ].
Potassium chloride label, warningsInteraction with Potassium-Sparing Diuretics Hypokalemia should not be treated by the concomitant administration of potassium salts and a potassium-sparing diuretic (e.g., spironolactone, triamterene, or amiloride) since the simultaneous administration of these agents can produce severe hyperkalemia.
Klor-Con label (Upsher-Smith Laboratories, LLC, July 14, 2025), contraindicationsCONTRAINDICATIONS Potassium chloride is contraindicated in patients on triamterene and amiloride. Concomitant use with triamterene and amiloride
Klor-Con label (Upsher-Smith Laboratories, LLC, July 14, 2025), drug interactionsDRUG INTERACTIONS Triamterene and amiloride: Concomitant use is contraindicated ( 7.1 ) Renin-angiotensin-aldosterone inhibitors:
Source: FDA drug label (Klor-Con, NDA019123), Upsher-Smith Laboratories, LLC, effective July 14, 2025 (SPL set 1ff53330-065c-4213-9c0c-ac498621d09d), via openFDA
Source: FDA drug label (KLOR-CON M), Upsher-Smith Laboratories, LLC, effective July 14, 2025 (SPL set b89910f6-4ff5-4a62-8269-696f7c10e4f6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiloride | Potassium chloride | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.190 per tablet 5 mg tablet | $0.0828 per tablet 10 mEq tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once