Potassium Chloride and Spironolactone Interaction
Drug interaction information between Potassium Chloride and Spironolactone.
Potassium Chloride and Spironolactone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Potassium Chloride and Spironolactone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Spironolactone makes your body keep potassium, and taking it with a potassium supplement can cause the mineral to build up too much.
FDA Label Information
7.2 Renin-angiotensin-aldosterone Inhibitors Drugs that inhibit the renin-angiotensin-aldosterone system (RAAS) including angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), spironolactone, eplerenone, or aliskiren produce potassium retention by inhibiting aldosterone production.
Potassium Chloride Also Interacts With
- Amiloride major
- Eplerenone minor
- Aliskiren minor
- Glycopyrrolate minor
- Prenatal Multivitamin minor
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Potassium Chloride + Spironolactone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Spironolactone has 23 labeled pairs on file vs Potassium Chloride's 6. In the minor band specifically: Potassium Chloride has 5 (also Eplerenone, Aliskiren, Glycopyrrolate, Prenatal Multivitamin); Spironolactone has 14 (also Digoxin, Cholestyramine, Amlodipine/Valsartan, Enalapril).
What mechanism field is on file for Potassium Chloride and Spironolactone?
Spironolactone makes your body keep potassium, and taking it with a potassium supplement can cause the mineral to build up too much.
Potassium Chloride carries more major-labeled pairs than Spironolactone
SPL source-record counts only. This page's band is minor · classes on file: Potassium Chloride (Electrolyte Supplement); Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist).
Potassium Chloride has 1 major-labeled pair vs Spironolactone's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 5 minor · 6 total
- Other minor peers for Potassium Chloride
- Eplerenone
- Aliskiren
- Glycopyrrolate
- Prenatal Multivitamin
0 major · 9 moderate · 14 minor · 23 total
- Other minor peers for Spironolactone
- Digoxin
- Cholestyramine
- Amlodipine/Valsartan
- Enalapril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.