Aliskiren and Furosemide Interaction
Drug interaction information between Aliskiren and Furosemide.
Aliskiren and Furosemide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Aliskiren and Furosemide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aliskiren reduces the amount of furosemide that gets into your body, which can make the water pill less effective at removing fluid.
FDA Label Information
Furosemide: Oral coadministration of aliskiren and furosemide reduced exposure to furosemide. Monitor diuretic effects when furosemide is coadministered with aliskiren.
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Aliskiren + Furosemide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Aliskiren's 28. In the minor band specifically: Aliskiren has 3 (also Potassium Chloride, Potassium Citrate); Furosemide has 29 (also Methotrexate, Norepinephrine, Ethacrynic Acid, Indomethacin).
What mechanism field is on file for Aliskiren and Furosemide?
Aliskiren reduces the amount of furosemide that gets into your body, which can make the water pill less effective at removing fluid.
Aliskiren carries more major-labeled pairs than Furosemide
SPL source-record counts only. This page's band is minor · classes on file: Aliskiren (Direct Renin Inhibitor); Furosemide (Loop Diuretic).
Aliskiren has 22 major-labeled pairs vs Furosemide's 3. This page itself is in the minor band, not the major band.
22 major · 3 moderate · 3 minor · 28 total
- Other minor peers for Aliskiren
- Potassium Chloride
- Potassium Citrate
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Methotrexate
- Norepinephrine
- Ethacrynic Acid
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.