Albuterol and Digoxin Interaction
Drug interaction information between Albuterol and Digoxin.
Albuterol and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Albuterol and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Albuterol can lower the amount of digoxin in your blood, which might make the heart medicine less effective.
FDA Label Information
( 7.2 ) Digoxin: May decrease serum digoxin levels. Consider monitoring digoxin levels. 7.3 Digoxin Mean decreases of 16% to 22% in serum digoxin levels were demonstrated after single-dose intravenous and oral administration of albuterol, respectively, to normal volunteers who had received digoxin for 10 days.
Albuterol Also Interacts With
- Theophylline major
- Albuterol/Ipratropium moderate
- Atomoxetine moderate
- Glimepiride minor
- Insulin Aspart minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Albuterol + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Albuterol's 16. In the minor band specifically: Albuterol has 13 (also Glimepiride, Insulin Aspart, Insulin Degludec, Insulin Detemir); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Albuterol and Digoxin?
Albuterol can lower the amount of digoxin in your blood, which might make the heart medicine less effective.
Digoxin carries more major-labeled pairs than Albuterol
SPL source-record counts only. This page's band is minor · classes on file: Albuterol (Short-Acting Beta-2 Agonist); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Albuterol's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 13 minor · 16 total
- Other minor peers for Albuterol
- Glimepiride
- Insulin Aspart
- Insulin Degludec
- Insulin Detemir
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.