vericiguat
Brand names: Verquvo
Verquvo is a medicine that helps lower the risk of death and hospitalization from heart failure. It is for adults with long-term heart failure and a weak heart pump (ejection fraction less than 45%).
Drug Pricing (NADAC)
Brand Price
$21.57/unit
Generic Available
No
MSD
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Verquvo helps to reduce the risk of dying from heart problems.
Common side effects
Low blood pressure, Anemia (low red blood cell count)
Key warnings
Verquvo can harm an unborn baby.
How It Works
Verquvo is a soluble guanylate cyclase (sGC) stimulator. It works by helping blood vessels relax and widen. This makes it easier for your heart to pump blood.
How to Take It
Take Verquvo once a day with food. The usual starting dose is 5 mg. If you are at risk of low blood pressure, your doctor may start you on 2.5 mg. Your doctor may double your dose every 2 weeks until you reach 10 mg daily, depending on how well you tolerate the medicine. If you cannot swallow the tablet whole, you can crush it and mix it with water right before taking it.
Pregnancy & Breastfeeding
Do not take Verquvo if you are pregnant. It can cause harm to your unborn baby. Breastfeeding is not recommended while taking Verquvo.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
Storage
Store Verquvo at room temperature, between 68°F and 77°F.
Side Effects (from patient reports)
Based on 553 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 905 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2017–2025.
Total Reports
905
Death-Related Reports
135
Hospitalization Reports
215
Top Indication
Cardiac Failure
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | HYPOTENSION | 106 |
| 2 | DEATH | 90 |
| 3 | DIZZINESS | 65 |
| 4 | CARDIAC FAILURE | 60 |
| 5 | PRODUCT DOSE OMISSION ISSUE | 50 |
| 6 | NO ADVERSE EVENT | 44 |
| 7 | ANAEMIA | 35 |
| 8 | FATIGUE | 35 |
| 9 | BLOOD PRESSURE DECREASED | 34 |
| 10 | MALAISE | 34 |
| 11 | DYSPNOEA | 32 |
| 12 | NAUSEA | 29 |
| 13 | ASTHENIA | 27 |
| 14 | DIARRHOEA | 27 |
| 15 | PRODUCT USE ISSUE | 25 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Verquvo can harm an unborn baby. If you are a woman who can get pregnant, you must have a pregnancy test before starting Verquvo. You must use effective birth control while taking Verquvo and for 1 month after your last dose.
Common Questions
What should I do if I feel dizzy after taking Verquvo?
Can I take Verquvo with my other heart medications?
How long will I need to take Verquvo?
Can I drink alcohol while taking Verquvo?
What should I do if I have side effects?
Is it okay to stop taking Verquvo if I feel better?
Will Verquvo cure my heart failure?
How often will I need to see my doctor while taking Verquvo?
Can I drive while taking Verquvo?
What if I have trouble paying for my Verquvo prescription?
What are the common side effects of vericiguat?
What drug class is vericiguat?
Is vericiguat safe during pregnancy?
Related Medications in Soluble Guanylate Cyclase Stimulator
Other drugs grouped near vericiguat — same-class peers and common alternatives.
adenosine
Adenocard
Adenosine (Adenocard) is a medicine used to treat certain types of irregular heartbeats.
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amiodarone
Cordarone, Pacerone
Amiodarone (Pacerone) is a medicine used to treat life-threatening, irregular heartbeats.
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atropine
AtroPen
Atropine is a medicine that can temporarily block severe effects on your body.
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bumetanide
Bumex
Bumetanide is a water pill (diuretic).
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carvedilol
Coreg
Carvedilol is a medicine that lowers blood pressure and helps your heart work better.
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What the FDA Data Shows for vericiguat
The FDA label for vericiguat (sold under brand names such as Verquvo) classifies it as a prescription-only medication in the Soluble Guanylate Cyclase Stimulator class. Verquvo helps to reduce the risk of dying from heart problems. Official labeling lists 2 commonly reported side effects, including Low blood pressure, Anemia (low red blood cell count).
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 553 voluntary reports. Interaction data is drawn directly from FDA-approved prescribing information. NADAC pricing from CMS.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: January 21, 2026
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages