What the label lists and what reports show
Mepivacaine side effects
Mepivacaine's FDA label lists its adverse reactions in its own words. FAERS holds 1,144 reports naming it through July 30, 2026; the reaction reported most often, leaving out the conditions it is used for, product-use terms and outcomes, is dyspnoea (62 reports).
- Generic listed
Check it at the source: the mepivacaine FDA label on DailyMed (effective May 29, 2025, Septodont, Inc.); the FDA FAERS public dashboard.
What does the label list?
From the label: adverse reactionsReactions to SCANDONEST ® are characteristic of those associated with other amide-type local anesthetics. Systemic adverse reactions involving the central nervous system and the cardiovascular system usually result from high plasma levels (which may be due to excessive dosage, rapid absorption, inadvertent intravascular injection, or slow metabolic degradation), injection technique, or volume of injection. A small number of reactions may result from hypersensitivity, idiosyncrasy or diminished tolerance to normal dosage on the part of the patient. Persistent paresthesias of the lips, tongue, and oral tissues have been reported with the use of mepivacaine, with slow, incomplete, or no recovery. These post-marketing events have been reported chiefly following nerve blocks in the mandible and have involved the trigeminal nerve and its branches. …
Source: FDA drug label, ANDA088387 (Deproco), as published by Septodont, Inc., effective May 29, 2025 (SPL set af6ff5f6-7221-421b-9b7c-8fcee4a47772), via openFDA; the full label on DailyMed
What do FAERS reports show?
1,144 reports list mepivacaine among the medicines taken, each a report of something that happened, not proof the medicine caused it; 46 are coded as a death and 380 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is. Of the 23 reactions below, 3 are named by the same term (in US spelling) in the label's adverse reactions, warnings or patient leaflet; a reaction the label does not name may still be there under another word, and a report does not show that the medicine caused it.
Reports received each year
The 25 most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; reactions as MedDRA preferred terms
What next?
- Mepivacaine: the full record
- label, generics, price, shortages, recalls
- Report a side effect to the FDA
- MedWatch
- Side effects hub
- the most reported medicines and reactions