PlainMeds research, FDA and CMS files of October 8, 2026
Medicines with a boxed warning
664 of the 2102 medicines with a current FDA label on this site have a boxed warning on at least one of their labels (for some, only one form or route, such as an injection); by class, Opioids (opioid agonists) have the most (29).
What the data shows
| Medicine | Pharmacologic class |
|---|---|
| Abacavir | Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor |
| Abacavir and dolutegravir and lamivudine | Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor, Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor, Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor |
| Abacavir and lamivudine | Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor, Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor |
| Abacavir and lamivudine and zidovudine | Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor, Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor |
| Abrocitinib | Janus Kinase Inhibitor |
| Acellular tissue engineered vessel | |
| Acetaminophen | |
| Acetaminophen and benzhydrocodone | |
| Acetaminophen and butalbital | Barbiturate |
| Acetaminophen and butalbital and caffeine | Barbiturate, Central Nervous System Stimulant, Methylxanthine |
| Acetaminophen and caffeine and dihydrocodeine | Central Nervous System Stimulant, Methylxanthine, Opioid Agonist |
| Acetaminophen and codeine | Opioid Agonist |
| Acetaminophen and hydrocodone | Opioid Agonist |
| Acetaminophen and ibuprofen | Nonsteroidal Anti-inflammatory Drug |
| Acetaminophen and oxycodone | Opioid Agonist |
| Acetaminophen and tramadol | Opioid Agonist |
| Acetaminophen, butalbital, caffeine and codeine | Barbiturate, Central Nervous System Stimulant, Methylxanthine, Opioid Agonist |
| Acetyl l-tyrosine, alanine and 15 other ingredients | Amino Acid |
| Acitretin | Retinoid |
| Adalimumab | Tumor Necrosis Factor Blocker |
| Adalimumab-aacf | |
| Adalimumab-aaty | |
| Adalimumab-adbm | |
| Adalimumab-afzb | |
| Adalimumab-fkjp | |
| Adalimumab-ryvk | |
| Adefovir dipivoxil | Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor |
| Aficamten | |
| Agalsidase beta | Hydrolytic Lysosomal Neutral Glycosphingolipid-specific Enzyme |
| Alanine, arginine and 17 other ingredients | Amino Acid |
| Aldesleukin | Lymphocyte Growth Factor |
| Alemtuzumab | CD52-directed Cytolytic Antibody |
| Alglucosidase alfa | Hydrolytic Lysosomal Glycogen-specific Enzyme |
| Aliskiren | Renin Inhibitor |
| Alogliptin and metformin | Biguanide, Dipeptidyl Peptidase 4 Inhibitor |
| Alogliptin and pioglitazone | Dipeptidyl Peptidase 4 Inhibitor, Peroxisome Proliferator Receptor alpha Agonist, Peroxisome Proliferator Receptor gamma Agonist, Thiazolidinedione |
| Alosetron | Serotonin-3 Receptor Antagonist |
| Alprazolam | Benzodiazepine |
| Alvimopan | Opioid Antagonist |
| Ambrisentan | Endothelin Receptor Antagonist |
| Amikacin | Aminoglycoside Antibacterial |
| Amiloride | Potassium-sparing Diuretic |
| Amiloride and hydrochlorothiazide | Potassium-sparing Diuretic, Thiazide Diuretic |
| Amiodarone | Antiarrhythmic |
| Amitriptyline | Tricyclic Antidepressant |
| Amitriptyline and chlordiazepoxide | Benzodiazepine, Tricyclic Antidepressant |
| Amitriptyline and perphenazine | Phenothiazine, Tricyclic Antidepressant |
| Amlodipine and benazepril | Angiotensin Converting Enzyme Inhibitor, Calcium Channel Blocker, Dihydropyridine Calcium Channel Blocker |
| Amlodipine and hydrochlorothiazide and olmesartan | Angiotensin 2 Receptor Blocker, Calcium Channel Blocker, Dihydropyridine Calcium Channel Blocker, Thiazide Diuretic |
| Amlodipine and hydrochlorothiazide and valsartan | Angiotensin 2 Receptor Blocker, Calcium Channel Blocker, Dihydropyridine Calcium Channel Blocker, Thiazide Diuretic |
| Amlodipine and indapamide and telmisartan | Angiotensin 2 Receptor Blocker, Calcium Channel Blocker, Dihydropyridine Calcium Channel Blocker, Thiazide-like Diuretic |
| Amlodipine and olmesartan | Angiotensin 2 Receptor Blocker, Calcium Channel Blocker, Dihydropyridine Calcium Channel Blocker |
| Amlodipine and telmisartan | Angiotensin 2 Receptor Blocker, Calcium Channel Blocker, Dihydropyridine Calcium Channel Blocker |
| Amlodipine and valsartan | Angiotensin 2 Receptor Blocker, Calcium Channel Blocker, Dihydropyridine Calcium Channel Blocker |
| Amoxapine | Tricyclic Antidepressant |
| Amphetamine | Central Nervous System Stimulant |
| Amphetamine and dextroamphetamine | Central Nervous System Stimulant |
| Andexanet alfa | |
| Anti-inhibitor coagulant complex | |
| Apixaban | Factor Xa Inhibitor |
The table shows the first 60 of 664 rows.
Source: FDA drug labels (Structured Product Labeling) via openFDA, read October 8, 2026
How it was measured
The boxed_warning section of each medicine's quoted FDA label (openFDA drug/label); the label chosen is the reference product's where the Orange Book names one.
What it cannot show
Labels of the same medicine from different makers can differ; a medicine without a current label in openFDA is not counted.