linezolid vs trazodone
Side-by-side comparison of linezolid and trazodone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Intervention: Trazodone is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [see Contraindications (4), Dosage and Administration (2.3, 2.4), and Warnings and Precautions (5.2)].
Recommendation: Do not take these two medications together. Your doctor will need to find an alternative treatment for you.
Linezolid is an antibiotic that fights bacteria in your body. It is used to treat different types of infections.
Trazodone is a medicine used to treat depression. It helps to improve your mood and can help you sleep better.
Linezolid treats pneumonia, skin infections, and infections caused by certain drug-resistant bacteria. It can treat pneumonia that you get in the hospital or in the community. It also treats complicated and uncomplicated skin infections, including diabetic foot infections. Linezolid can also treat infections caused by vancomycin-resistant Enterococcus faecium.
Trazodone is used to treat major depressive disorder (MDD) in adults. This medicine can help improve your mood and reduce symptoms of depression. Talk to your doctor if you have any questions about why you are taking this medication.
Linezolid works by stopping the growth of bacteria. It blocks bacteria from making proteins that they need to live and multiply. This helps your body fight off the infection.
Trazodone is a selective serotonin reuptake inhibitor (SSRI). It works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood.
- • Diarrhea
- • Vomiting
- • Headache
- • Nausea
- • Anemia
- • Swelling
- • Blurred vision
- • Fainting
- • Drowsiness
- • Tiredness
- Thrombocytopenia 2,032
- Anaemia 1,601
- Drug Interaction 1,381
- Nausea 1,301
- Vomiting 1,063
- Tiredness 1,129
- Feeling sick to your stomach 1,097
- Head pain 906
- General discomfort 806
- Loose stools 792
Linezolid can cause several serious side effects. It can lower your blood cell counts, so your doctor will monitor your blood. It can also cause nerve problems, especially if you take it for more than 28 days. Tell your doctor right away if you have vision changes, numbness, or tingling. Linezolid can also interact with certain antidepressants and cause a dangerous condition called serotonin syndrome. Diarrhea can also occur.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor will monitor you closely for worsening depression or suicidal thoughts. Trazodone is not approved for use in children.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if linezolid will harm your unborn baby. It can pass into breast milk, so talk to your doctor about breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. It is important to consider the risk of untreated depression during pregnancy. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can register by calling 1-844-405-6185.
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How to Read This linezolid vs trazodone Comparison
linezolid is classified in the Oxazolidinone Antibiotic drug class, while trazodone sits within the Serotonin Antagonist and Reuptake Inhibitor (SARI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, linezolid has 7,378 submissions while trazodone has 4,730. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to linezolid acts like a special type of medicine that can cause a dangerous buildup of a brain chemical called serotonin when mixed with trazodone. this can lead to a serious condition called serotonin syndrome.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between linezolid and trazodone - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.