hydrochlorothiazide vs tolterodine
Side-by-side comparison of hydrochlorothiazide and tolterodine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Diuretics Coadministration of tolterodine immediate release up to 8 mg (4 mg bid) for up to 12 weeks with diuretic agents, such as indapamide, hydrochlorothiazide, triamterene, bendroflumethiazide, chlorothiazide, methylchlorothiazide, or furosemide, did not cause any adverse electrocardiographic (ECG) effects.
Recommendation: No dosage adjustments are necessary when using these two medications at the same time.
Microzide
Detrol
No summary available.
Tolterodine extended-release capsules help control an overactive bladder. It reduces the feeling of needing to go to the bathroom often.
Information not available.
This medicine treats overactive bladder. It helps reduce leaking urine, the strong need to urinate, and frequent urination. These symptoms are also known as urge urinary incontinence, urgency, and frequency.
Information not available.
Tolterodine belongs to a class of drugs called antimuscarinics. It works by blocking certain nerve signals to the bladder. This helps to relax the bladder muscles and reduce the urge to urinate.
- • Dizziness
- • Headache
- • Cough
- • Fatigue
- • Dry mouth
- • Headache
- • Constipation
- • Abdominal pain
- Tiredness 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- Discomfort 7,665
- Difficulty breathing 7,584
- Falling down 407
- Feeling tired 406
- Feeling lightheaded 309
- Loose stools 308
- Feeling sick to your stomach 308
No specific warnings noted.
Anaphylaxis and angioedema (severe allergic reactions) have happened with this drug. These reactions can cause difficulty breathing and require emergency treatment. Use caution if you have bladder problems, gastrointestinal issues, or glaucoma. This medicine can cause sleepiness, so be careful driving or operating heavy machinery.
No pregnancy information available.
It is not known if tolterodine is safe to use during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if tolterodine passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking this medicine.
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How to Read This hydrochlorothiazide vs tolterodine Comparison
hydrochlorothiazide is classified in the Thiazide Diuretic drug class, while tolterodine sits within the Anticholinergic (Overactive Bladder) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, hydrochlorothiazide has 43,279 submissions while tolterodine has 1,738. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to studies show that taking these two drugs together does not cause any dangerous changes to your heart rhythm.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between hydrochlorothiazide and tolterodine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.