Clozapine · larger labeled portfolio than Terbinafine
SPL labels Terbinafine + Clozapine as minor; Terbinafine 16 / Clozapine 39 in that band.
Mechanism on file: Terbinafine blocks the enzymes that normally clear clozapine from your system, which can lead to higher levels of clozapine and more side effects.
FDA SPL severity: Minor
Terbinafine + Clozapine · SPL mechanism field
Terbinafine blocks the enzymes that normally clear clozapine from your system, which can lead to higher levels of clozapine and more side effects.
Minor band excerpt · Terbinafine with Clozapine
CYP2D6 and CYP3A4 Inhibitors Concomitant treatment with VERSACLOZ and CYP2D6 or CYP3A4 inhibitors (e.g., cimetidine, escitalopram, erythromycin, paroxetine, bupropion, fluoxetine, quinidine, duloxetine, terbinafine, or sertraline) can increase clozapine levels and lead to adverse reactions [see Clinical Pharmacology (12.3) ] .
Terbinafine · 16 minor + 17 total pairs
- Amiodarone minor
- Cimetidine minor
- Cyclosporine minor
- Desipramine minor
Clozapine · 42 SPL pairs (broader portfolio than Terbinafine)
- Amiodarone minor
- Bupropion minor
- Carbamazepine minor
- Chlorpromazine minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.