Amiodarone · more major-labeled pairs than Terbinafine
SPL labels Terbinafine + Amiodarone as minor; Terbinafine 16 / Amiodarone 29 in that band.
Mechanism on file: Amiodarone blocks the enzymes that break down terbinafine, which can cause terbinafine levels to rise in your body.
FDA SPL severity: Minor
Terbinafine + Amiodarone · SPL mechanism field
Amiodarone blocks the enzymes that break down terbinafine, which can cause terbinafine levels to rise in your body.
Minor band excerpt · Terbinafine with Amiodarone
Based on this finding, it is likely that other inhibitors of both CYP2C9 and CYP3A4 (e.g., ketoconazole, amiodarone) may also lead to a substantial increase in the systemic exposure (C max and AUC) of terbinafine when concomitantly administered.
Terbinafine · 16 minor + 17 total pairs
- Cimetidine minor
- Clozapine minor
- Cyclosporine minor
- Desipramine minor
Amiodarone · 4 major-labeled pairs (vs Terbinafine's 0)
- Atenolol minor
- Atorvastatin minor
- Carvedilol minor
- Cholestyramine minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.