duloxetine vs temazepam
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Side-by-side comparison of duloxetine and temazepam. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.6 Temazepam Under steady-state conditions for duloxetine (20 mg qhs) and temazepam (30 mg qhs), the pharmacokinetics of duloxetine were not affected by co-administration.
Cymbalta
Restoril
Duloxetine is a medicine that can help treat depression and anxiety. It can also help with certain types of pain.
Temazepam is a medicine that helps you sleep. It is used for a short time to treat insomnia.
Duloxetine can treat major depressive disorder and generalized anxiety disorder in adults and children (7 years and older). It can also treat diabetic nerve pain, fibromyalgia, and chronic muscle or bone pain in adults. In children, it can treat fibromyalgia (13 years and older).
Temazepam capsules are used to treat insomnia. Insomnia means you have trouble falling asleep or staying asleep. This medicine is only for short-term use, usually for 7 to 10 days.
Duloxetine is a type of drug called an SNRI. It works by increasing the levels of serotonin and norepinephrine in your brain. These chemicals can help improve mood and reduce pain.
Temazepam belongs to a class of drugs called benzodiazepines. It works by slowing down activity in the brain. This helps you to relax and fall asleep.
- • Nausea
- • Dry mouth
- • Sleepiness
- • Constipation
- • Decreased appetite
- • Drowsiness
- • Headache
- • Fatigue
- • Nervousness
- • Lethargy
- Fatigue 4,787
- Nausea 4,782
- Pain 3,697
- Headache 3,654
- Diarrhoea 3,262
- Fatigue 2,804
- Nausea 2,399
- Pain 2,271
- Headache 2,234
- Toxicity To Various Agents 2,129
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Watch closely for worsening depression or suicidal thoughts. Tell your doctor right away if you notice any changes in mood or behavior.
Taking temazepam with opioid medicines can cause very serious problems, including slowed breathing, coma, and death. Only take them together if there are no other options. Temazepam can be misused or lead to addiction, which can result in overdose or death. Using temazepam for a long time can cause you to become dependent on it. Stopping it suddenly can cause life-threatening withdrawal symptoms. Your doctor will slowly lower your dose to prevent withdrawal.
Using duloxetine in the last month of pregnancy may cause problems in the newborn. Talk to your doctor about the risks and benefits of taking duloxetine during pregnancy. Women who stop taking antidepressants during pregnancy are more likely to experience a relapse of depression.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if temazepam will harm your unborn baby. Talk to your doctor if you are breastfeeding.
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How to Read This duloxetine vs temazepam Comparison
duloxetine is classified in the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) drug class, while temazepam sits within the Benzodiazepine (Hypnotic) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, duloxetine has 20,182 submissions while temazepam has 11,837. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these two medications do not change how the body processes duloxetine when they are taken together.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for duloxetine or temazepam.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.