Safinamide and Linezolid Interaction
Drug interaction information between Safinamide and Linezolid.
Safinamide and Linezolid have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Safinamide and Linezolid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs stop the body from breaking down certain chemicals, which can lead to a toxic buildup in your system.
FDA Label Information
7 DRUG INTERACTIONS Selective Serotonin Reuptake Inhibitors: Monitor patients for serotonin syndrome ( 7.3 ) Sympathomimetic Medications: Monitor patients for hypertension ( 7.5 ) Tyramine: Risk of severe hypertension ( 7.6 ) 7.1 MAO Inhibitors (MAOIs) XADAGO is contraindicated for use with other drugs in the MAOIs class or other drugs that are potent inhibitors of monoamine oxidase (e.g., linezolid, an oxazolidinone antibacterial, which also has reversible nonselective MAO inhibition activity).
Safinamide Also Interacts With
- Tramadol major
- Methylphenidate major
- Methadone major
- Meperidine major
- Dextromethorphan major
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Tranylcypromine major
Frequently Asked Questions
What SPL severity band is on file for Safinamide + Linezolid?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Linezolid has 29 labeled pairs on file vs Safinamide's 10. In the major band specifically: Safinamide has 6 (also Tramadol, Methylphenidate, Methadone, Meperidine); Linezolid has 8 (also Citalopram, Escitalopram, Mirtazapine, Paroxetine).
What mechanism field is on file for Safinamide and Linezolid?
Both drugs stop the body from breaking down certain chemicals, which can lead to a toxic buildup in your system.
Linezolid carries more major-labeled pairs than Safinamide
SPL source-record counts only. This page's band is major · classes on file: Safinamide (MAO-B Inhibitor); Linezolid (Oxazolidinone Antibiotic).
Linezolid has 8 major-labeled pairs vs Safinamide's 6.
6 major · 0 moderate · 4 minor · 10 total
- Other major peers for Safinamide
- Tramadol
- Methylphenidate
- Methadone
- Meperidine
8 major · 3 moderate · 18 minor · 29 total
- Other major peers for Linezolid
- Citalopram
- Escitalopram
- Mirtazapine
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.