Safinamide and Dextromethorphan Interaction
Drug interaction information between Safinamide and Dextromethorphan.
Safinamide and Dextromethorphan have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Safinamide and Dextromethorphan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Safinamide is an MAO inhibitor, and taking it with dextromethorphan can cause serious mental side effects like psychosis or strange behavior.
FDA Label Information
7.4 Dextromethorphan The combination of MAOIs and dextromethorphan has been reported to cause episodes of psychosis or bizarre behavior. Therefore, in view of XADAGO's MAO inhibitory activity, dextromethorphan is contraindicated for use with XADAGO.
Safinamide Also Interacts With
- Tramadol major
- Methylphenidate major
- Linezolid major
- Methadone major
- Meperidine major
Dextromethorphan Also Interacts With
- Memantine moderate
- Rasagiline moderate
- Tranylcypromine moderate
- Abiraterone minor
- Aripiprazole minor
Frequently Asked Questions
What SPL severity band is on file for Safinamide + Dextromethorphan?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dextromethorphan has 15 labeled pairs on file vs Safinamide's 10. In the major band specifically: Safinamide has 6 (also Tramadol, Methylphenidate, Linezolid, Methadone); Dextromethorphan has 1.
What mechanism field is on file for Safinamide and Dextromethorphan?
Safinamide is an MAO inhibitor, and taking it with dextromethorphan can cause serious mental side effects like psychosis or strange behavior.
Safinamide carries more major-labeled pairs than Dextromethorphan
SPL source-record counts only. This page's band is major · classes on file: Safinamide (MAO-B Inhibitor); Dextromethorphan (Antitussive).
Safinamide has 6 major-labeled pairs vs Dextromethorphan's 1.
6 major · 0 moderate · 4 minor · 10 total
- Other major peers for Safinamide
- Tramadol
- Methylphenidate
- Linezolid
- Methadone
1 major · 3 moderate · 11 minor · 15 total
Dextromethorphan has no other major-band peer in this dataset besides Safinamide.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.