Safinamide and Meperidine Interaction
Drug interaction information between Safinamide and Meperidine.
Safinamide and Meperidine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Safinamide and Meperidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can cause a severe, life-threatening reaction by interfering with how the brain handles certain chemicals.
FDA Label Information
7.2 Opioid Drugs Because serious, sometimes fatal reactions have been precipitated with concomitant use of opioid drugs (e.g., meperidine and its derivatives, methadone, propoxyphene, or tramadol) and MAOIs, including selective MAO-B inhibitors, concomitant use of these drugs is contraindicated [see Warnings and Precautions (5.2) ] .
Safinamide Also Interacts With
- Tramadol major
- Methylphenidate major
- Linezolid major
- Methadone major
- Dextromethorphan major
Meperidine Also Interacts With
- Rasagiline moderate
- Tranylcypromine moderate
- Gabapentin minor
- Trazodone minor
- Tramadol minor
Frequently Asked Questions
What SPL severity band is on file for Safinamide + Meperidine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Meperidine has 31 labeled pairs on file vs Safinamide's 10. In the major band specifically: Safinamide has 6 (also Tramadol, Methylphenidate, Linezolid, Methadone); Meperidine has 1.
What mechanism field is on file for Safinamide and Meperidine?
This combination can cause a severe, life-threatening reaction by interfering with how the brain handles certain chemicals.
Safinamide carries more major-labeled pairs than Meperidine
SPL source-record counts only. This page's band is major · classes on file: Safinamide (MAO-B Inhibitor); Meperidine (Opioid Analgesic).
Safinamide has 6 major-labeled pairs vs Meperidine's 1.
6 major · 0 moderate · 4 minor · 10 total
- Other major peers for Safinamide
- Tramadol
- Methylphenidate
- Linezolid
- Methadone
1 major · 2 moderate · 28 minor · 31 total
Meperidine has no other major-band peer in this dataset besides Safinamide.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.