gemfibrozil vs rosiglitazone
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of gemfibrozil and rosiglitazone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7 DRUG INTERACTIONS Inhibitors of CYP2C8 (e.g., gemfibrozil) may increase rosiglitazone levels. (7.2) 7.1 Drugs Metabolized by Cytochrome P450 An inhibitor of CYP2C8 (e.g., gemfibrozil) may increase the AUC of rosiglitazone and an inducer of CYP2C8 (e.g., rifampin) may decrease the AUC of rosiglitazone.
Lopid
Avandia
Gemfibrozil is a medicine that helps lower high triglyceride levels in your blood. It can also help reduce the risk of heart disease in some people.
No summary available.
This medicine is used to treat very high triglyceride levels in adults when diet alone doesn't work. High triglycerides can increase your risk of pancreatitis. Gemfibrozil can also lower the risk of heart disease in some people with specific cholesterol problems.
Information not available.
Gemfibrozil belongs to a class of drugs called fibrates. It works by decreasing the amount of triglycerides your body makes. It also helps to increase HDL (good) cholesterol.
Information not available.
- • Upset stomach
- • Indigestion
- • Abdominal pain
- • Nausea
- • Vomiting
- • Diarrhea
- • Headache
- • Upset stomach
- Nausea 883
- Fatigue 825
- Diarrhoea 726
- Pain 693
- Dizziness 617
No adverse event reports.
This medicine may increase your risk of gallbladder problems, including the need for surgery. Before taking gemfibrozil, tell your doctor if you have liver or kidney problems. You should not take this medicine with simvastatin, repaglinide, dasabuvir, or selexipag.
No specific warnings noted.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if gemfibrozil can harm your unborn baby. It is also not known if gemfibrozil passes into breast milk.
No pregnancy information available.
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How to Read This gemfibrozil vs rosiglitazone Comparison
gemfibrozil is classified in the Fibrate drug class, while rosiglitazone sits within the Thiazolidinedione class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, gemfibrozil has 3,744 submissions while rosiglitazone has 0. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to gemfibrozil blocks a specific liver protein that normally breaks down rosiglitazone. this can cause the levels of rosiglitazone in your blood to rise.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for gemfibrozil or rosiglitazone.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.