ranitidine vs risperidone
Side-by-side comparison of ranitidine and risperidone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Dose adjustment is not recommended for risperidone tablets when co-administered with ranitidine, cimetidine, amitriptyline, or erythromycin [see Table 18 ] . Do not exceed twice the patient’s usual dose Enzyme (CYP3A) inhibitors Ranitidine 150 mg twice daily 1 mg single dose 1.2 1.4 Dose adjustment not needed Cimetidine 400 mg twice daily 1 mg single dose 1.1 1.3 Dose adjustment not needed Erythromycin 500 mg four times daily 1 mg single dose 1.1 0.94 Dose adjustment not needed Other Drugs Amitriptyline 50 mg twice daily 3 mg twice daily 1.2 1.1 Dose adjustment not Needed *Change relative...
Recommendation: No dose adjustment is necessary when these two medications are used together.
Zantac
Risperdal
Ranitidine (Zantac) helps reduce stomach acid. It can relieve heartburn and sour stomach.
Risperidone is a medicine used to treat certain mental disorders. It can help reduce symptoms like hallucinations, delusions, and aggression.
This medicine treats heartburn caused by acid indigestion and sour stomach. You can also take it to prevent heartburn. It can prevent heartburn caused by eating or drinking certain foods and drinks.
Risperidone is used to treat schizophrenia in adults and teens. It also treats manic or mixed episodes of bipolar I disorder, either alone or with lithium or valproate. Additionally, it can help with irritability, including aggression and self-injury, in children and teens with autism.
Ranitidine is an H2 receptor antagonist. It works by blocking histamine. Blocking histamine reduces the amount of acid your stomach makes.
Risperidone works by changing the levels of certain natural substances in the brain. These substances are called neurotransmitters. By balancing these chemicals, risperidone can reduce symptoms of mental disorders.
- • Headache
- • Parkinsonism (slowed movement, stiffness)
- • Restlessness
- • Muscle stiffness or spasms
- • Tremors
- • Sleepiness
- Breast cancer 24,853
- Prostate cancer 22,252
- Colon and rectal cancer 17,674
- Bladder cancer 16,746
- Kidney cancer 16,278
- Breast enlargement in males 24,608
- Unusual weight gain 9,446
- Weight gain 9,089
- Mental or emotional problem 5,947
- Harm or damage to the body 4,624
No specific warnings noted.
Risperidone may increase the risk of death in elderly patients who have dementia-related psychosis. Risperidone is not approved for treating dementia-related psychosis.
No pregnancy information available.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who take risperidone in the last 3 months of pregnancy may have withdrawal symptoms or other problems after birth. There is a pregnancy registry to monitor outcomes in women exposed to risperidone during pregnancy. You can contact the registry at 1-866-961-2388.
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How to Read This ranitidine vs risperidone Comparison
ranitidine is classified in the H2 Receptor Antagonist drug class, while risperidone sits within the Atypical Antipsychotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ranitidine has 97,803 submissions while risperidone has 53,714. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to ranitidine causes a small increase in risperidone levels, but it is not enough to change how the drug works or its safety.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between ranitidine and risperidone - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.