raloxifene vs warfarin
Side-by-side comparison of raloxifene and warfarin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
(7.1 , 12.3) Warfarin : Monitor prothrombin time when starting or stopping raloxifene hydrochloride. 7.2 Warfarin If raloxifene hydrochloride is given concomitantly with warfarin or other warfarin derivatives, prothrombin time should be monitored more closely when starting or stopping therapy with raloxifene hydrochloride [see Clinical Pharmacology (12.3) ] .
Recommendation: Your doctor should monitor your blood clotting tests more closely when you start or stop taking raloxifene.
Evista
Coumadin, Jantoven
Raloxifene (Evista) is a medicine that can help treat and prevent bone loss (osteoporosis) in women after menopause. It can also lower the chance of getting a certain type of breast cancer.
Warfarin is a medicine that helps prevent blood clots. It is used to treat and prevent dangerous clots from forming in your body.
This medicine is used to treat and prevent osteoporosis in women after menopause. It can also lower the risk of invasive breast cancer in women after menopause who have osteoporosis or are at high risk of getting it. This medicine is not for treating breast cancer, lowering the risk of breast cancer coming back, or lowering the risk of non-invasive breast cancer.
Warfarin is used to prevent and treat blood clots in your veins and lungs. It can also prevent clots if you have atrial fibrillation (irregular heartbeat) or a replacement heart valve. After a heart attack, it can lower the risk of death, another heart attack, or a stroke.
Raloxifene belongs to a class of drugs called Selective Estrogen Receptor Modulators (SERMs). It works like estrogen in some parts of the body, such as bones, which helps to prevent bone loss. But it blocks estrogen's effects in other parts of the body, like the breast, which can help prevent certain types of breast cancer.
Warfarin works by blocking your body's use of vitamin K. Vitamin K is needed to make blood clotting factors. By blocking vitamin K, warfarin makes your blood less likely to clot.
- • Hot flashes
- • Leg cramps
- • Swelling in your legs or feet
- • Flu-like symptoms
- • Joint pain
- • Bleeding from any tissue or organ
- Feeling tired 143
- Joint pain 109
- Diarrhea 109
- Falling down 107
- Feeling sick to your stomach 106
- INR increased 10,275
- Shortness of breath 8,408
- Interaction with another medicine 6,289
- Tiredness 6,141
- Feeling sick to your stomach 5,921
Raloxifene can increase your risk of blood clots in your veins (deep vein thrombosis) and lungs (pulmonary embolism). If you have had blood clots in the past, you should not take this medicine. Raloxifene can also increase the risk of death from stroke in women who have heart disease or are at risk for heart problems. Talk to your doctor about the risks and benefits of taking raloxifene if you are at risk for stroke.
Warfarin can cause major or fatal bleeding. You must have your blood tested regularly (INR) while taking warfarin. Many things, like other medicines and diet changes, can affect your INR. Tell your doctor about any bleeding and follow their instructions to prevent bleeding.
You should not take this medicine if you are pregnant or could become pregnant. It may harm your unborn baby. Do not use this medicine if you are breastfeeding.
Warfarin can harm your unborn baby, especially during the first three months of pregnancy. Do not take warfarin if you are pregnant, unless you have a mechanical heart valve and your doctor says the benefits outweigh the risks. Talk to your doctor if you are breastfeeding, and watch your baby for bruising or bleeding.
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How to Read This raloxifene vs warfarin Comparison
raloxifene is classified in the Selective Estrogen Receptor Modulator (SERM) drug class, while warfarin sits within the Vitamin K Antagonist (Anticoagulant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, raloxifene has 574 submissions while warfarin has 37,034. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to raloxifene can affect how warfarin thins your blood, which might change your risk of bleeding or blood clots.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between raloxifene and warfarin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.