Quetiapine and Itraconazole Interaction
Drug interaction information between Quetiapine and Itraconazole.
Quetiapine and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Quetiapine and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole slows down how fast your body gets rid of quetiapine, which can cause the medicine to build up to high levels.
FDA Label Information
Quetiapine exposure is increased by the prototype CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, etc.) and decreased by the prototype CYP3A4 inducers (e.g., phenytoin, carbamazepine, rifampin, avasimibe, St.
Quetiapine Also Interacts With
- Clarithromycin major
- Darunavir moderate
- Ketoconazole minor
- Carbamazepine minor
- Rifampin minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Quetiapine + Itraconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Quetiapine's 9. In the minor band specifically: Quetiapine has 7 (also Ketoconazole, Carbamazepine, Rifampin, Dopamine); Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone).
What mechanism field is on file for Quetiapine and Itraconazole?
Itraconazole slows down how fast your body gets rid of quetiapine, which can cause the medicine to build up to high levels.
Itraconazole carries more major-labeled pairs than Quetiapine
SPL source-record counts only. This page's band is minor · classes on file: Quetiapine (Atypical Antipsychotic); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Quetiapine's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 7 minor · 9 total
- Other minor peers for Quetiapine
- Ketoconazole
- Carbamazepine
- Rifampin
- Dopamine
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.