Quetiapine and Itraconazole Interaction
Drug interaction information between Quetiapine and Itraconazole.
Quetiapine and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Quetiapine and Itraconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Itraconazole slows down how fast your body gets rid of quetiapine, which can cause the medicine to build up to high levels.
What To Do
Your doctor may need to lower your quetiapine dose to one-sixth of the normal amount while taking this combination.
FDA Label Information
Quetiapine exposure is increased by the prototype CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, etc.) and decreased by the prototype CYP3A4 inducers (e.g., phenytoin, carbamazepine, rifampin, avasimibe, St.
Quetiapine Also Interacts With
- Clarithromycin major
- Darunavir moderate
- Ketoconazole minor
- Carbamazepine minor
- Rifampin minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
Can I take Quetiapine and Itraconazole together?
This is a minor interaction. Your doctor may need to lower your quetiapine dose to one-sixth of the normal amount while taking this combination.
How serious is the interaction between Quetiapine and Itraconazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Quetiapine and Itraconazole interact?
Itraconazole slows down how fast your body gets rid of quetiapine, which can cause the medicine to build up to high levels.
Understanding the Quetiapine and Itraconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Quetiapine belongs to the Atypical Antipsychotic class and Itraconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Itraconazole slows down how fast your body gets rid of quetiapine, which can cause the medicine to build up to high levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Quetiapine has 9 total documented interactions on file in this dataset, and Itraconazole has 116. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to lower your quetiapine dose to one-sixth of the normal amount while taking this combination. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Quetiapine or Itraconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.