What the FDA labels say about taking them together
Quetiapine and rifampin
Quetiapine's FDA label of April 10, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name quetiapine. The quetiapine label: “Concomitant use of strong CYP3A4 inducers: Increase quetiapine dose up to 5 fold when used in combination with a chronic treatment (more than 7-14 days) of potent CYP3A4 inducers”
Check it at the source: the quetiapine FDA label on DailyMed (effective April 10, 2026, H2-Pharma, LLC); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the quetiapine label say about rifampin?
Quetiapine label, drug interactionsConcomitant use of strong CYP3A4 inducers: Increase quetiapine dose up to 5 fold when used in combination with a chronic treatment (more than 7-14 days) of potent CYP3A4 inducers (e.g., phenytoin, rifampin, St. John’s wort)
Source: FDA drug label (SEROQUEL), NDA020639 (Cheplapharm), as published by H2-Pharma, LLC, effective April 10, 2026 (SPL set 8ae62aaf-f8c5-417f-baac-0098369ca322), via openFDA; the full label on DailyMed
What does the rifampin label say about quetiapine?
Rifampin's label (effective February 11, 2026) does not name quetiapine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Quetiapine | Rifampin | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder, Depression | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.127 per tablet 300 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once