Quetiapine and Rifampin Interaction
Drug interaction information between Quetiapine and Rifampin.
Quetiapine and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Quetiapine and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the process of your body breaking down quetiapine, which lowers the amount of medicine in your blood.
FDA Label Information
7 DRUG INTERACTIONS Concomitant use of strong CYP3A4 inhibitors: Reduce quetiapine dose to one sixth when coadministered with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) ( 2.5 , 7.1 , 12.3 ) Concomitant use of strong CYP3A4 inducers: Increase quetiapine dose up to 5 fold when used in combination with a chronic treatment (more than 7-14 days) of potent CYP3A4 inducers (e.g., phenytoin, rifampin, St. Quetiapine exposure is increased by the prototype CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, etc.) and decreased by the prototype CYP3A4...
Quetiapine Also Interacts With
- Clarithromycin major
- Darunavir moderate
- Ketoconazole minor
- Carbamazepine minor
- Itraconazole minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Quetiapine + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Quetiapine's 9. In the minor band specifically: Quetiapine has 7 (also Ketoconazole, Carbamazepine, Itraconazole, Dopamine); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Quetiapine and Rifampin?
Rifampin speeds up the process of your body breaking down quetiapine, which lowers the amount of medicine in your blood.
Rifampin carries more major-labeled pairs than Quetiapine
SPL source-record counts only. This page's band is minor · classes on file: Quetiapine (Atypical Antipsychotic); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Quetiapine's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 7 minor · 9 total
- Other minor peers for Quetiapine
- Ketoconazole
- Carbamazepine
- Itraconazole
- Dopamine
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.