Quetiapine and Clarithromycin Interaction
Drug interaction information between Quetiapine and Clarithromycin.
Quetiapine and Clarithromycin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Quetiapine and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin stops your body from breaking down quetiapine, which can cause the drug to build up to toxic levels.
FDA Label Information
Colchicine (in patients with normal renal and hepatic function) Use With Caution Antipsychotics: Pimozide Contraindicated Pimozide: [See Contraindications ( 4.2 )] Quetiapine Lurasidone Quetiapine: Quetiapine is a substrate for CYP3A4, which is inhibited by clarithromycin. Co‑administration with clarithromycin could result in increased quetiapine exposure and possible quetiapine related toxicities. Refer to quetiapine prescribing information for recommendations on dose reduction if co‑administered with CYP3A4 inhibitors such as clarithromycin.
Quetiapine Also Interacts With
- Darunavir moderate
- Ketoconazole minor
- Carbamazepine minor
- Rifampin minor
- Itraconazole minor
Clarithromycin Also Interacts With
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
- Pimozide major
Frequently Asked Questions
What SPL severity band is on file for Quetiapine + Clarithromycin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Quetiapine's 9. In the major band specifically: Quetiapine has 1; Clarithromycin has 16 (also Pioglitazone, Fluconazole, Cyclosporine, Lurasidone).
What mechanism field is on file for Quetiapine and Clarithromycin?
Clarithromycin stops your body from breaking down quetiapine, which can cause the drug to build up to toxic levels.
Clarithromycin carries more major-labeled pairs than Quetiapine
SPL source-record counts only. This page's band is major · classes on file: Quetiapine (Atypical Antipsychotic); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Quetiapine's 1.
1 major · 1 moderate · 7 minor · 9 total
Quetiapine has no other major-band peer in this dataset besides Clarithromycin.
16 major · 35 moderate · 30 minor · 81 total
- Other major peers for Clarithromycin
- Pioglitazone
- Fluconazole
- Cyclosporine
- Lurasidone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.