amoxicillin/clavulanate vs progesterone
Side-by-side comparison of amoxicillin/clavulanate and progesterone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.4 Oral Contraceptives AUGMENTIN may affect intestinal flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
Recommendation: Use a backup method of birth control, such as condoms, while taking this antibiotic to prevent pregnancy.
Augmentin
Prometrium
Augmentin is a combination of two medicines, amoxicillin and clavulanate. It is an antibiotic that fights bacteria in your body.
Progesterone capsules contain a hormone that helps regulate your menstrual cycle and supports pregnancy. It is also used to prevent overgrowth of the uterine lining in women taking estrogen after menopause.
Augmentin treats infections caused by bacteria. It is used for infections such as lower respiratory infections, ear infections, sinus infections, skin infections, and urinary tract infections. This medicine will not work for viral infections, such as colds or the flu.
Progesterone capsules are used to prevent the lining of the uterus from growing too much in women who have gone through menopause and are taking estrogen. This medicine is also used to restart menstrual periods that have stopped in women who are not pregnant or going through menopause. This condition is called secondary amenorrhea.
Amoxicillin kills bacteria. Clavulanate helps amoxicillin work better by preventing bacteria from breaking down amoxicillin. This combination helps to fight a wider range of bacteria.
Progesterone is a hormone naturally produced by your body. This medicine works by increasing progesterone levels in your body. This helps to regulate your menstrual cycle and protect the uterus.
- • Diarrhea or loose stools
- • Nausea
- • Skin rashes
- • Hives
- • Vomiting
- • Headache
- • Breast tenderness
- • Joint pain
- • Depression
- • Dizziness
- Long-term kidney disease 4,661
- Sudden kidney damage 4,200
- Diarrhea 4,083
- Drug allergy 3,744
- Feeling sick to your stomach 3,700
- Headache 1,946
- Tiredness 1,673
- Pain 1,369
- Feeling sick to your stomach 1,362
- Skin rash 903
Augmentin can cause serious allergic reactions, including fatal ones. Stop taking Augmentin and get medical help right away if you have any signs of an allergic reaction. Augmentin can also cause severe skin reactions. Tell your doctor if you develop a rash. This drug can also cause liver problems and severe diarrhea.
Estrogen plus progestin therapy should not be used to prevent heart disease or dementia. Estrogen plus progestin may increase your risk of blood clots, stroke, heart attack, breast cancer, and dementia. Progesterone with estrogens should be prescribed at the lowest effective doses and for the shortest duration.
Animal studies show Augmentin may be safe during pregnancy, but there are no good studies in pregnant women. Talk to your doctor if you are pregnant or plan to become pregnant. Amoxicillin passes into breast milk and may cause problems for the baby, so talk to your doctor if you are breastfeeding.
You should not take progesterone capsules if you are pregnant or think you might be pregnant. Talk to your doctor if you become pregnant while taking this medicine. It is not known if progesterone passes into breast milk. Talk to your doctor about the risks and benefits of breastfeeding while taking this medicine.
How to Read This amoxicillin/clavulanate vs progesterone Comparison
amoxicillin/clavulanate is classified in the Penicillin / Beta-Lactamase Inhibitor Combination drug class, while progesterone sits within the Progestogen Hormone class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amoxicillin/clavulanate has 20,388 submissions while progesterone has 7,253. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to this antibiotic can change the bacteria in your gut, which makes it harder for your body to absorb the hormones in birth control pills.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between amoxicillin/clavulanate and progesterone - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.