Dolutegravir and Rifampin Interaction
Drug interaction information between Dolutegravir and Rifampin.
Dolutegravir and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dolutegravir and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the breakdown of dolutegravir, which can make it less effective.
FDA Label Information
Rifampin a ↓Dolutegravir In adults and in pediatric patients weighing at least 25 kg , adjust dolutegravir dose to 50 mg twice daily.
Dolutegravir Also Interacts With
- Dofetilide major
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
- Linagliptin moderate
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Dolutegravir + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Dolutegravir's 28. In the minor band specifically: Dolutegravir has 21 (also Omeprazole, Prednisone, Estradiol, Carbamazepine); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Dolutegravir and Rifampin?
Rifampin speeds up the breakdown of dolutegravir, which can make it less effective.
Rifampin carries more major-labeled pairs than Dolutegravir
SPL source-record counts only. This page's band is minor · classes on file: Dolutegravir (Integrase Strand Transfer Inhibitor); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Dolutegravir's 1. This page itself is in the minor band, not the major band.
1 major · 6 moderate · 21 minor · 28 total
- Other minor peers for Dolutegravir
- Omeprazole
- Prednisone
- Estradiol
- Carbamazepine
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.