norepinephrine vs tranylcypromine
Side-by-side comparison of norepinephrine and tranylcypromine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Excessive reduction of blood glucose (additive effect) [See Warnings and Precautions (5.14)] ; CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution Increased CNS depression Dietary supplements containing sympathomimetics Contraindicated Antidepressants including but not limited to: • Other MAOIs (e.g., linezolid, intravenous methylene blue, selective MAOIs) • Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) • Tricyclic antidepressants • Amoxapine, bupropion, maprotiline, nefazodone, trazodone,...
Recommendation: Avoid using these drugs at the same time. If they must be used in a hospital setting, your vital signs must be monitored constantly by medical staff.
Levophed
Parnate
Norepinephrine injection raises blood pressure in adults with very low blood pressure. It belongs to a class of drugs called vasopressors.
Tranylcypromine (Parnate) is a medicine used to treat major depression in adults. It is used when other antidepressants have not worked well enough.
This medicine treats severe, sudden low blood pressure in adults. Low blood pressure can happen due to serious conditions. Norepinephrine helps to restore blood pressure to help blood flow to vital organs.
Tranylcypromine is used to treat major depressive disorder (MDD) in adults. You should only use it if other antidepressants haven't helped. It is not for the first treatment of depression because it can cause serious side effects and has many drug and food interactions.
Norepinephrine works by tightening blood vessels. This increases blood pressure. It helps to improve blood flow to your organs.
Tranylcypromine belongs to a class of drugs called MAO inhibitors. It works by increasing the levels of certain chemicals in your brain. These chemicals can help improve your mood.
- • High blood pressure
- • Slow heart rate
- • Anxiety
- • Headache
- • Trouble breathing
- • Dry mouth
- • Dizziness
- • Trouble sleeping
- • Feeling sleepy
- • Headache
- Low blood pressure 1,011
- Sudden kidney damage 747
- Failure of multiple organs 652
- Poisoning from different substances 624
- Condition getting worse 560
- Interaction between medicines 68
- Feeling sad or hopeless 36
- Too much serotonin in the body 27
- Head pain 24
- High blood pressure 24
Norepinephrine can cause tissue damage if it leaks out of the vein. The medicine can also cause very low blood pressure if stopped suddenly. It may also cause irregular heartbeats, especially if you have heart problems. Allergic reactions are possible due to the sulfite ingredient.
Tranylcypromine can increase the risk of suicidal thoughts and behaviors in young adults. It can also cause a dangerous increase in blood pressure if you eat foods high in tyramine or take certain medicines. Make sure to follow all food and drug restrictions.
This medicine may be used during pregnancy if needed. Low blood pressure during pregnancy can be dangerous for both mother and baby. Talk to your doctor about the risks and benefits.
There is limited information about the safety of tranylcypromine during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not recommended to breastfeed while taking this medicine because it can harm the baby.
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How to Read This norepinephrine vs tranylcypromine Comparison
norepinephrine is classified in the Vasopressor (Alpha-1 Agonist) drug class, while tranylcypromine sits within the Monoamine Oxidase Inhibitor (MAOI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, norepinephrine has 3,594 submissions while tranylcypromine has 179. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to this combination stops the body from clearing norepinephrine, which can cause blood pressure to rise to levels that may cause a stroke or heart attack.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between norepinephrine and tranylcypromine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.