darunavir vs midazolam
Side-by-side comparison of darunavir and midazolam. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Sedatives/hypnotics: orally administered midazolam, triazolam ↑ midazolam ↑ triazolam Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as prolonged or increased sedation or respiratory depression. Triazolam and orally administered midazolam are extensively metabolized by CYP3A. Co-administration of triazolam or orally administered midazolam with darunavir may cause large increases in the concentrations of these benzodiazepines.
Recommendation: You should not take these two medicines together because the combination can be life-threatening.
Darunavir is a medicine used to treat HIV. It belongs to a class of drugs called protease inhibitors and must be taken with ritonavir.
Midazolam is a medicine that makes you feel calm, relaxed, and sleepy. It can also cause you to forget things that happen while you are taking it.
Darunavir is used to treat HIV-1 infection in adults and children 3 years and older. It must be taken with ritonavir and other HIV medicines. Darunavir helps to lower the amount of HIV in your body.
Midazolam is used to sedate you before a surgery or procedure to help you relax and feel less anxious. It can also be used to help you feel calm during procedures like bronchoscopies or endoscopies. Midazolam can also be used to start general anesthesia before you get other medicines.
Darunavir is a protease inhibitor. It works by blocking an enzyme called protease that HIV needs to make copies of itself. This helps to slow down the spread of HIV in your body.
Midazolam belongs to a class of drugs called benzodiazepines. It works by slowing down activity in your brain and nervous system. This helps to reduce anxiety, promote relaxation, and cause sleepiness.
- • Diarrhea
- • Nausea
- • Rash
- • Headache
- • Abdominal pain
- • Decreased breathing rate
- • Tenderness at the injection site
- • Pain during injection
- Baby exposed to drug during pregnancy 1,150
- Interaction between medicines 981
- Pain 889
- Emotional upset 812
- Worry 811
- Convulsions 1,373
- Low blood pressure 1,296
- Medicine affecting another medicine 1,088
- Poisoning from different substances 846
- Sudden kidney damage 845
Darunavir can cause liver problems. Your doctor should check your liver before you start taking darunavir and during treatment. Tell your doctor right away if you have any signs of liver problems, such as yellowing of the skin or eyes.
Midazolam can cause serious breathing problems, including slowed or stopped breathing. This is more likely to happen if you are also taking opioid pain medicines. You must be closely monitored by trained medical staff while receiving midazolam. Make sure the facility has the equipment and medicines needed to treat breathing problems immediately.
Tell your doctor if you are pregnant or plan to become pregnant. The recommended dose during pregnancy is 600 mg twice daily with ritonavir 100mg and food. Women with HIV should not breastfeed because HIV can be passed to the baby through breast milk.
Tell your doctor if you are pregnant or plan to become pregnant. Midazolam may harm an unborn baby. It is not known if midazolam passes into breast milk. Talk to your doctor about the risks and benefits of using this medicine while breastfeeding.
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How to Read This darunavir vs midazolam Comparison
darunavir is classified in the HIV Protease Inhibitor drug class, while midazolam sits within the Benzodiazepine class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, darunavir has 4,643 submissions while midazolam has 5,448. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to darunavir blocks the enzyme that breaks down midazolam, causing the sedative to build up in your body. this can lead to dangerously deep sleep or breathing problems.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between darunavir and midazolam - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.