Rivastigmine and Oxybutynin Interaction
Drug interaction information between Rivastigmine and Oxybutynin.
Rivastigmine and Oxybutynin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rivastigmine and Oxybutynin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These drugs have opposite effects on the body. Rivastigmine can prevent oxybutynin from working the way it is supposed to.
What To Do
Tell your doctor if your symptoms return, as they may need to change your medications.
FDA Label Information
7.2 Cholinomimetic and Anticholinergic Medications Rivastigmine tartrate may increase the cholinergic effects of other cholinomimetic medications and may also interfere with the activity of anticholinergic medications (e.g., oxybutynin, tolterodine).
Rivastigmine Also Interacts With
- Metoclopramide moderate
- Atenolol minor
- Tolterodine minor
Oxybutynin Also Interacts With
- Ketoconazole minor
- Erythromycin minor
- Clarithromycin minor
- Itraconazole minor
- Metoclopramide minor
Frequently Asked Questions
Can I take Rivastigmine and Oxybutynin together?
This is a minor interaction. Tell your doctor if your symptoms return, as they may need to change your medications.
How serious is the interaction between Rivastigmine and Oxybutynin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Rivastigmine and Oxybutynin interact?
These drugs have opposite effects on the body. Rivastigmine can prevent oxybutynin from working the way it is supposed to.
Understanding the Rivastigmine and Oxybutynin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Rivastigmine belongs to the Acetylcholinesterase Inhibitor class and Oxybutynin belongs to the Anticholinergic / Antispasmodic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These drugs have opposite effects on the body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Rivastigmine has 4 total documented interactions on file in this dataset, and Oxybutynin has 7. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Tell your doctor if your symptoms return, as they may need to change your medications. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Rivastigmine or Oxybutynin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.