Methyldopa and Enalapril Interaction
Drug interaction information between Methyldopa and Enalapril.
Methyldopa and Enalapril have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Methyldopa and Enalapril. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications work in different ways to lower blood pressure and have been used together without causing significant safety issues.
FDA Label Information
Other Cardiovascular Agents Enalapril maleate has been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine, prazosin and digoxin without evidence of clinically significant adverse interactions.
Methyldopa Also Interacts With
- Ferrous Sulfate moderate
- Carbidopa/Levodopa moderate
- Tranylcypromine moderate
- Lithium minor
- Colestipol minor
Enalapril Also Interacts With
- Aliskiren major
- Spironolactone minor
- Hydralazine minor
- Lithium minor
- Prazosin minor
Frequently Asked Questions
What SPL severity band is on file for Methyldopa + Enalapril?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Enalapril has 16 labeled pairs on file vs Methyldopa's 7. In the minor band specifically: Methyldopa has 4 (also Lithium, Colestipol, Vasopressin); Enalapril has 15 (also Spironolactone, Hydralazine, Lithium, Prazosin).
What mechanism field is on file for Methyldopa and Enalapril?
These medications work in different ways to lower blood pressure and have been used together without causing significant safety issues.
Enalapril carries more major-labeled pairs than Methyldopa
SPL source-record counts only. This page's band is minor · classes on file: Methyldopa (Central Alpha-2 Agonist); Enalapril (ACE Inhibitor).
Enalapril has 1 major-labeled pair vs Methyldopa's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 4 minor · 7 total
- Other minor peers for Methyldopa
- Lithium
- Colestipol
- Vasopressin
1 major · 0 moderate · 15 minor · 16 total
- Other minor peers for Enalapril
- Spironolactone
- Hydralazine
- Lithium
- Prazosin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.