Methyldopa and Lithium Interaction
Drug interaction information between Methyldopa and Lithium.
Methyldopa and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Methyldopa and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Methyldopa can cause lithium to build up in the body to levels that are not safe.
FDA Label Information
When methyldopa and lithium are given concomitantly, the patient should be carefully monitored for symptoms of lithium toxicity. Read the circular for lithium preparations.
Methyldopa Also Interacts With
- Ferrous Sulfate moderate
- Carbidopa/Levodopa moderate
- Tranylcypromine moderate
- Colestipol minor
- Enalapril minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Methyldopa + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Methyldopa's 7. In the minor band specifically: Methyldopa has 4 (also Colestipol, Enalapril, Vasopressin); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Methyldopa and Lithium?
Methyldopa can cause lithium to build up in the body to levels that are not safe.
Lithium carries more major-labeled pairs than Methyldopa
SPL source-record counts only. This page's band is minor · classes on file: Methyldopa (Central Alpha-2 Agonist); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Methyldopa's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 4 minor · 7 total
- Other minor peers for Methyldopa
- Colestipol
- Enalapril
- Vasopressin
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.