methadone vs tranylcypromine
Side-by-side comparison of methadone and tranylcypromine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Recommendation: It is best to avoid taking these drugs together. If they are necessary, your doctor will need to monitor you very closely for any signs of a bad reaction and use the lowest effective doses.
Dolophine
Parnate
Methadone Hydrochloride Injection is a strong pain medicine. It is also used to treat opioid dependence temporarily when you cannot take medicine by mouth.
Tranylcypromine (Parnate) is a medicine used to treat major depression in adults. It is used when other antidepressants have not worked well enough.
This medicine is used to manage severe, ongoing pain that needs a strong opioid medicine when other pain medicines don't work well enough. It is also used for the short-term treatment of opioid dependence when you cannot take oral medication, such as if you are in the hospital. Injectable methadone is not approved for outpatient treatment of opioid dependence.
Tranylcypromine is used to treat major depressive disorder (MDD) in adults. You should only use it if other antidepressants haven't helped. It is not for the first treatment of depression because it can cause serious side effects and has many drug and food interactions.
Methadone works by attaching to opioid receptors in the brain and body. This changes how your body feels pain. It can also help reduce withdrawal symptoms if you are opioid dependent.
Tranylcypromine belongs to a class of drugs called MAO inhibitors. It works by increasing the levels of certain chemicals in your brain. These chemicals can help improve your mood.
- • Lightheadedness
- • Dizziness
- • Sedation
- • Nausea
- • Vomiting
- • Dry mouth
- • Dizziness
- • Trouble sleeping
- • Feeling sleepy
- • Headache
- Addiction to the drug 5,614
- Harmful effects from different substances 5,213
- Misuse of the drug 4,797
- Taking too much of the drug 3,841
- Pain 3,669
- Interaction between medicines 68
- Feeling sad or hopeless 36
- Too much serotonin in the body 27
- Head pain 24
- High blood pressure 24
Methadone Hydrochloride Injection can cause serious and life-threatening risks, including addiction, abuse, and misuse. It can also cause life-threatening breathing problems, especially when you first start taking it or after a dose increase. Using methadone during pregnancy can cause withdrawal symptoms in the newborn. Using methadone with benzodiazepines or other drugs that can cause drowsiness, including alcohol, can cause severe sedation, breathing problems, coma, and death. Methadone can also cause a serious heart problem called QT prolongation.
Tranylcypromine can increase the risk of suicidal thoughts and behaviors in young adults. It can also cause a dangerous increase in blood pressure if you eat foods high in tyramine or take certain medicines. Make sure to follow all food and drug restrictions.
Using Methadone Hydrochloride Injection during pregnancy can cause withdrawal symptoms in the newborn. Talk to your doctor about the risks and benefits of using this medicine if you are pregnant or plan to become pregnant. It is not known if methadone passes into breast milk, so talk to your doctor before breastfeeding.
There is limited information about the safety of tranylcypromine during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not recommended to breastfeed while taking this medicine because it can harm the baby.
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How to Read This methadone vs tranylcypromine Comparison
methadone is classified in the Opioid Agonist drug class, while tranylcypromine sits within the Monoamine Oxidase Inhibitor (MAOI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, methadone has 23,134 submissions while tranylcypromine has 179. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to this combination can lead to life-threatening issues like extremely high blood pressure or serotonin syndrome. these drugs interfere with the way the body processes chemicals that regulate pain, mood, and heart rate.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between methadone and tranylcypromine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.